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HPLC法测定盐酸左氧氟沙星片的溶出度

彭博 董斌 田洁 王戈 邹亮

中国药物评价2016,Vol.33Issue(1):1-2,6,3.
中国药物评价2016,Vol.33Issue(1):1-2,6,3.

HPLC法测定盐酸左氧氟沙星片的溶出度

Determination of the Dissolution Rate of Levofloxacin Hydrochloride Tablets by HPLC

彭博 1董斌 1田洁 1王戈 1邹亮1

作者信息

  • 1. 大连市药品检验所,辽宁大连116021
  • 折叠

摘要

Abstract

Objective:To establish high performance liquid chromatography ( HPLC) to achieve the determination of the dissolution rate of levofloxacin hydrochloride tablets.Methods:Thermo Hypersil Gold C18 (4.6 mm ×150 mm, 5μm) chromatographic column was adopted through the sodium perchlorate solution-ammonium acetate acetonitrile (85∶15) as mobile phase, flow rate of 1 mL· min-1 , col-umn temperature 30℃, detection wavelength of 294 nm.Results:The linear regression equation of levofloxacin hydrochloride dissolution rate was Y=35601X+1268.3, r=0.9997, the average recovery was 99.6%, RSD was 0.70%.Conclusion: HPLC was simple and convenient with high accuracy and well repeatability.

关键词

高效液相色谱/溶出度/左氧氟沙星片

Key words

High performance liquid chromatography/Dissolution rate/Levofloxacin hydrochloride tablets

分类

医药卫生

引用本文复制引用

彭博,董斌,田洁,王戈,邹亮..HPLC法测定盐酸左氧氟沙星片的溶出度[J].中国药物评价,2016,33(1):1-2,6,3.

中国药物评价

2095-3593

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