中国药物评价2016，Vol.33Issue(1)：3-6,4.
湿热痹片质量标准研究
Quality Standards Research of Shirebi Tablets
董斌 1刘静 1季雪 1彭博 1邵建芳 2施法3
作者信息
- 1. 大连市药品检验所，辽宁大连116021
- 2. 大连市药品不良反应监测中心，辽宁大连116021
- 3. 辽宁省药品检验检测院，辽宁沈阳110000
- 折叠
摘要
Abstract
Objective:To establish a quality standard for shirebi tablets.Methods:The TLC method was used for thequalitative iden-tification of Fourstamen Stephania Root, Cortex Phellodendri Amurensis and Pheretima Aspergillum.The content of Phillyrin was determind by HPLC.HPLC was carried on with a Agilent ZORBAX SB-C18 (4.6 mm ×250 mm,5μm) column, acetonitrile-0.1%phosphoric acid (20∶80) as the mobile phase at the flow rate of 1.0 mL· min-1.Results:The identification studys showed strong specificity.The calibra-tion curves were linear in the range of 0.01665-0.1665μg for Phillyrin.The average recovery rate was 99.5%with RSD 1.1%(n=9).Conclusion:The method is accrate with a good reproducibility,and suitable for quality control of shirebi tablets.关键词
湿热痹片/质量标准/薄层色谱法/连翘苷/高效液相色谱法Key words
Shirebi tablets/Quality control/TLC/Phillyrin/HPLC分类
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董斌,刘静,季雪,彭博,邵建芳,施法..湿热痹片质量标准研究[J].中国药物评价,2016,33(1):3-6,4.
