中国医学装备2016，Vol.13Issue(4)：71-74,75,5.DOI:10.3969/J.ISSN.1672-8270.2016.04.022
超声双重造影对胃癌伴肝内转移患者新辅助化疗疗效预测的价值研究
Prediction efficacy of neoadjuvant chemotherapy in the treatment of liver metastasis from gastric cancer with double contrast-enhanced ultrasonography
徐娟 1赵晔 2李俊芝 1崔永慧 1杨德瑞 1赵静1
作者信息
- 1. 沧州市中心医院超声介入诊断治疗科 河北 沧州 061000
- 2. 沧州市中心医院骨一科 河北 沧州 061000
- 折叠
摘要
Abstract
Objective:To evaluate and predict the efficacy of neoadjuvant chemotherapy(NAC) in the treatment of liver metastasis from gastric cancer with double contrast-enhanced ultrasonography.Methods: Eight two patients with liver metastasis from gastric cancer accepted double contrast-enhanced ultrasonography before and after three cycle NAC. Microvessel density(MVD) was calculated in the resected gastric carcinoma specimens via immunohistochemical staining. Parameters of double contrast-enhanced ultrasonography before and after NAC were compared, and the parameters between different pathologic effect groups were analyzed. Analysis of correlation between MVD and parameters, 62 cases were in effective group, other 20 cases in progressing group.Results: Peak intensity(PI) of all the patients after three cycle of NAC was significantly reduce. Rising time(RT)and time to peak(TTP)after three cycle of NAC was significantly extension. After three cycle of NAC PI of effective group was significantly lower than progressing group. Change rate of peak intensity(CROPI) of effective group after three cycle of NAC was significantly higher than advances group. After three cycle of NAC TTP and CROPI were negative correlation with MVD (rTTP=-6.32,rCPOPI=-0.742,P<0.01).Conclusion:PI and CROPI of double contrast-enhanced ultrasonography can predict the effect of NAC for liver metastasis from gastric cancer, and CROPI has higher sensitivity.关键词
超声双重造影/胃肿瘤诱导化疗超声检查预测/微血管密度Key words
Stomach neoplasms/Induction chemotherapy/Ultrasonography/Forecasting分类
医药卫生引用本文复制引用
徐娟,赵晔,李俊芝,崔永慧,杨德瑞,赵静..超声双重造影对胃癌伴肝内转移患者新辅助化疗疗效预测的价值研究[J].中国医学装备,2016,13(4):71-74,75,5.
