中国中西医结合影像学杂志2016，Vol.14Issue(3)：239-242,245,5.DOI:10.3969/j.issn.1672-0512.2016.03.002
肝豆状核变性患者灰质结构MRI形态学初步研究
Preliminary MRI morphology study on cerebral gray matter in Wilson’s disease
摘要
Abstract
Objective:To investigate the cerebral gray matter volume in Wilson’s disease (WD) with voxel-based morphometry (VBM). Methods:30 cases of WD patients and 30 cases of healthy volunteers were recruited to get three-dimensional (3D) brain structures image with GE 3.0 T MRI scanner. The data preprocessing was performed with VBM,and then the differences in volume between two groups were demonstrated by statistical analysis with the program of AFNI,corrected using false discov-ery rate (FDR) simulations with P=0.001,α<0.05. Results:Compared to controls,WD patients showed decreasing gray matter vol-ume in bilateral caudate nucleus,globus pallidus,thalamus,cerebellum,pons,precentral gyrus,postcentral gyrus,insular lobe,mid-dle frontal gyrus and left posterior cingulated,pulvinar. Besides,increasing gray matter volume were also observed in bilateral insular lobe and corpus callosum,right superior temporal gyrus,superior frontal gyrus,red nucleus and left of middle temporal gyrus,medial frontal gyrus. Conclusion:Decreasing gray matter volume is widespread in brain of WD patients,and increasing gray matter volume in several cerebral regions,which might significantly correlated with the clinical symptoms.关键词
肝豆状核变性/灰质/基于体素的形态测量学/磁共振成像Key words
Hepatolenticular degeneration/Gray matter/Voxel-based morphometry/Magnetic resonance imaging引用本文复制引用
张春芸,王安琴,武红利,汤岚凤,徐春生,卢琦,李传富..肝豆状核变性患者灰质结构MRI形态学初步研究[J].中国中西医结合影像学杂志,2016,14(3):239-242,245,5.基金项目
国家973计划项目（2010CB530505）；安徽中医药大学青年科学研究基金（2015qn016）。 （）
