中华耳科学杂志2016，Vol.14Issue(1)：10-14,5.DOI:10.3969/j.issn.1672-2922.2016.01.003
荣昌猪遗传性听力缺陷家系的发掘与应用
Excavation and application of the Rongchang Pig hereditary pedigree connected to hearing defects
摘要
Abstract
As a different class of animal model from mice, pig is being highly valued in areas including comparative biology, developmental biology, medical genetics and animal husbandry. Our representation describes a variation of the unique Rongchang pig strain-Rongchang hereditary pedigree connected to hearing defects . The mutation sites, pathology and pathogenesis are very similar to those in human Waardenburg syndrome type 2A. Application of this pedigree, in the field of hearing research, benefits the study on treatment of neurosensory hearing loss with stem cell transplantation, early genetic intervention, auditory device implantation, etc. Moreover, it provides an ideal model of large mammals with respect to hearing medicine sciences.关键词
荣昌猪/动物模型/听觉医学Key words
Rongchang pig/animal model/hearing medicine science分类
医药卫生引用本文复制引用
陈伟,陈磊,杨仕明..荣昌猪遗传性听力缺陷家系的发掘与应用[J].中华耳科学杂志,2016,14(1):10-14,5.基金项目
国家973计划重大科学问题导向项目（2011CBA01000）；国家自然科学基金面上项目（81271082）；国家自然科学基金青年项目（81400472）；北京科技创新基地培育与发展专项；重庆市基本科研业务费项目 （）
