中华耳科学杂志2016，Vol.14Issue(1)：37-42,6.DOI:10.3969/j.issn.1672-2922.2016.01.008
腺相关病毒在耳聋基因治疗上的应用
Application of adeno-associated virus gene vectors in hereditary non-syndromic sensorineural hearing loss
摘要
Abstract
Adeno-associated virus has been used in gene therapies due to its unique gene vector advantages. Large amount of literature has demonstrated successful use of adeno-associated virus carrying various target genes in animal mod-els of hereditary hearing loss with different approaches, to be expressed in hair cells, stria vascularis, support cells, spiral ganglion cells, etc, for the purpose of restoration of morphology and function. This paper summarizes the application of ade-no-associated virus gene vectors in hereditary hearing loss, its advantages, successful experiences and problems in the past, and shares new ideas in its utilities in the future.关键词
腺相关病毒/遗传性耳聋/基因治疗/载体Key words
adeno-associated virus/hereditary hearing loss/gene therapy/vectors分类
医药卫生引用本文复制引用
史珣贝,吴南,郭维维,杨仕明,林昶..腺相关病毒在耳聋基因治疗上的应用[J].中华耳科学杂志,2016,14(1):37-42,6.基金项目
国家973计划重大科学研究计划干细胞项目（2012CB967900）；国家973计划重大科学问题导向项目（2011CBA01000)；国家863青年科学家项目（2014AA020510）；国家自然科学基金青年项目（面上项目81271082，青年基金81400472）；国家自然科学基金（81470684）；北京科技创新基地培育与发展专项（z151100001615050）；重庆市基本科研业务费项目 （）
