中华临床免疫和变态反应杂志2016，Vol.10Issue(1)：15-20,6.DOI:10.3969/j.issn.1673-8705.2016.01.004
血清抗M型磷脂酶A2受体抗体对特发性膜性肾病的诊断价值
Diagnostic Value of Serum M-type Phospholipase A2 Receptor Antibody in Patients with Idiopathic Membranous Nephropathy
摘要
Abstract
Objective ToinvestigatethediagnosticvalueofserumM-typephospholipaseA2receptorantibody (anti-PLA2 R)in patients with idiopathic membranous nephropathy(IMN)and the correlation between anti-PLA2Randurineprotein.Methods Atotalof76patientswithrenalbiopsy-provedglomerulardiseasewere enrolled in this study,including 20 cases with IMN,20 cases with lupus nephritis (LN),16 cases with hepatitis B virus associated nephropathy (HBV-GN),and 20 cases with IgA nephropathy (IgAN).Eight healthy controls were also enrolled. The parameters of urinary albumin/creatinine ratio (UAlb/Cr),24 hour urinary protein secretion level (24hPro),serum creatinine (Scr),blood urea nitrogen (BUN)and serum <br> albumin (Alb)were measured. The serum anti-PLA2 R levels were detected by a ELISA kit. The levels of serum anti-PLA2R were compared among the five groups,and the correlation between serum anti-PLA2R with UAlb/Cr and 24hPro were analyzed. ROC curve was plotted to determine the diagnostic sector of serum anti-PLA2RinpredictingIMN.Results Thelevelsofserumanti-PLA2RinpatientswithIMN[(23.66± 4. 06)μg/L] were higher than the LN group [(17. 92 ±3. 13 )μg/L],HBV-GN group [(14. 33 ± 4. 43)μg/L],IgAN group [(13. 68 ±1. 81)μg/L],and the control group [(11. 65 ±3. 08)μg/L]. Correlation analysis found that the serum anti-PLA2 R levels are positively correlated with UAlb/Cr (r =0. 795,P<0. 001)and 24hPro (r=0. 531,P=0. 016)in patients with IMN. ROC curve showed that the area under the curve was 0. 938 (95% CI:0. 881 -0. 996).The clinical diagnostic sector of anti-PLA2R indiagnosingIMNwas19.07μg/l(sensitivity95.0%,specificity79.1%).Conclusions Serumanti-PLA2 R levels are positively correlated with urine protein in patients with IMN,and it may be a novel serum biomarker for predicting IMN with high sensitivity and specificity.关键词
抗M型磷脂酶A2 受体抗体/特发性膜性肾病/诊断价值Key words
M-type phospholipase A2 receptor antibody/idiopathic membranous nephropathy/diagnostic value分类
医药卫生引用本文复制引用
邱杰山,胡良峰,张丽红,李青华,沈水娟..血清抗M型磷脂酶A2受体抗体对特发性膜性肾病的诊断价值[J].中华临床免疫和变态反应杂志,2016,10(1):15-20,6.基金项目
浙江省医学会临床科研基金 （）
