中华临床免疫和变态反应杂志2016，Vol.10Issue(1)：33-39,7.DOI:10.3969/j.issn.1673-8705.2016.01.007
链格孢变应原皮试液用于链格孢变态反应性疾病诊断的有效性和安全性
Accuracy and Safety of Alternaria alternata Extract Used for Intradermal Test in the Diagnosis of Alternaria alternata Allergy
王瑞琦 1王良录 1李宏 1孙劲旅 1利平 1顾建青 1关凯 1尹佳1
作者信息
- 1. 中国医学科学院 北京协和医学院 北京协和医院变态反应科，北京 100730
- 折叠
摘要
Abstract
Objective To evaluate the accuracy and safety of Alternaria alternata extract which was used for intradermal test in the diagnosis of Alternaria alternata allergy.Methods 1 043 patients who had been prescribed both intradermal skin tests (IDT)and serum specific IgE (sIgE).Detections were collected and reviewed from Department of Allergy,PUMC hospital since Apr.10th to Aug.10th 2009.The accuracy of IDT with Alternaria alternata extract was evaluated byusing clinical diagnoses of allergists and sIgE detection results as golden standards and relative golder standard respectively.Adverse reactions were also recorded.Results IDT results ≥ “+”was defined as the cutoff threshold for diagnosing.Sensitivity,specificity, positive predictive value,negative predictive value,accuracy and area under ROC curve was 0.886 4,0.894 5,0.500 0,0.985 1,0.893 6,0.915 (95% confidence interval 0.874,0.956)respectively by using clinical diagnoses of allergists as gold standard.Whereas sIgE results ≥ 0.35 KUA/L was defined as the cutoff threshold for diagnosing,sensitivity,specificity,positive predictive value,negative predictive value and accuracy was 0.927 7,0.531 3,0.719 6,0.850 0 and 0.755 1 respectively by using sIgE results as standard.Coefficient of rank correlation between sIgE and IDT results was 0.628 00(P <0.000 1) in serum sIgE positive group.Local adverse reactions were recorded in 0.48% (5 /1 043)patients,none of them was attacked by type Ⅰ systemic adverse reaction.Conclusion IDT with Alternaria alternata extract is anaccuracy and safe tool for the diagnosis of Alternaria alternata allergy.关键词
链格孢/皮内试验/有效性/安全性Key words
Alternaria alternata/intradermal test/accuracy/safety分类
医药卫生引用本文复制引用
王瑞琦,王良录,李宏,孙劲旅,利平,顾建青,关凯,尹佳..链格孢变应原皮试液用于链格孢变态反应性疾病诊断的有效性和安全性[J].中华临床免疫和变态反应杂志,2016,10(1):33-39,7.
