中华临床免疫和变态反应杂志2016，Vol.10Issue(1)：69-74,6.DOI:10.3969/j.issn.1673-8705.2016.01.013
天平的两端：活化性和抑制性Fcγ受体
Ends of the Scale:Activating and Inhibiting FcγReceptors
黄林芳 1廖湘平 1雷丽 1张烜 1郑文洁2
作者信息
- 1. 南华大学附属郴州市第一人民医院风湿免疫科，湖南郴州 423000
- 2. 中国医学科学院北京协和医学院北京协和医院风湿免疫科，北京 100730
- 折叠
摘要
Abstract
There are a variety of cells that could express different kinds or types of Ig Fc receptors,and they play an important role in promoting and regulating immune response, but FcγRⅡB is the only inhibitory receptor. A growing number of studies have shown that FcγRⅡB plays an important role in the pathogenesis of autoimmune diseases,such as systemic lupus erythematosus,rheumatoid arthritis. Several studies have shown that keep the balance between activating and inhibitory Fcγreceptor is very important,othernise,it will lead to many diseases, and FcγRⅡB can inhibits the function of activating FcγRs, such as phagocytosis,the inflammation induced by immune complex and the release of pro-inflammatory cytokins. Therefore,to clarify the relationship between FcγRⅡB and diseases,will be helpful to provide new treatment strategies for autoimmune diseases.关键词
FcγRⅡB/活化性Fcγ受体/抑制性Fcγ受体Key words
FcγRⅡB/activating Fcγreceptor/inhibitory Fcγreceptor分类
医药卫生引用本文复制引用
黄林芳,廖湘平,雷丽,张烜,郑文洁..天平的两端：活化性和抑制性Fcγ受体[J].中华临床免疫和变态反应杂志,2016,10(1):69-74,6.
