摘要
Abstract
Objective:To discuss the efficacy and safety of Nifedipine and Nimodipine in the treatment of primary hypertension.Method:100 patients with primary hypertension were randomly divided into the treatment group(n=48) and the control group(n=52),the control group was only given Nifedipine. The treatment group disabled all blood pressure drugs,oral Nifedipine 10 mg,Nimodipine 40 mg,3 times a day.After days of medication,Nifedipine increased to 60 mg a day, Nimodipine increased to 180 mg a day according to blood pressure,15 days later,maintained Nifedipine 30 mg a day,Nimodipine 120 mg a day,4 weeks for a course of treatment.Result:After 4 weeks of treatment,the blood pressure by an average of treatment group (177.0±9.8)/(106.0±9.8)mm Hg decreased to (132.0±9.0)/(90.0±2.3)mm Hg;Blood pressure by an average of the control group (176.0±9.9)/(107.0±9.7)mm Hg decreased to (138.0±9.1)/(95.0±2.2)mm Hg, the total effective rate of treatment group was 95.8%,the control group was 65.4%,the blood pressure and clinical efficacy differences were significant(P<0.05). Also 10 patients with angina pectoris attack stopped,16 patients with ST segment and T wave abnormalities had different degree of recovery,16 cases of ischemic cerebrovascular disease improved obviously in treatment group,control group had 2,8,6 cases respectively,the differences were significant(P<0.05). After treatment,4 cases had facial blushing,4 cases had headache(mainly pain) dizziness,the control group had 7,8 cases respectively.Conclusion:The combination therapy in primary hypertension have a curative effect and synergistic effects on the heart,the blood vessel of brain,and it can improve blood supply of cardiac and cerebral vascular,and can be clinically as ideal antihypertensive drugs for application.关键词
原发性高血压/硝苯吡啶/尼莫地平/疗效Key words
Essential hypertension/Nifedipine/Nimodipine/Curative effect分类
医药卫生
