波谱学杂志2016，Vol.33Issue(2)：208-223,16.DOI:10.11938/cjmr20160204
棕色脂肪组织和白色脂肪组织的代谢组学研究
Metabonomics Analysis of Brown Adipose and White Adipose Tissues
摘要
Abstract
Brown adipose tissue (BAT) plays a vital role in energy metabolism, and has been regarded as a novel potential drug target for treating obesity. However, the metabolic compositions of BAT and white adipose tissue (WAT) remain to be determined. We applied nuclear magnetic resonance (NMR) and gas chromatography (GC) based metabonomics approaches to characterize and compare the composition of water-soluble metabolites and fatty acids in BAT and WAT. The results indicated that these two types of adipose tissue have marked differences in carbohydrate metabolism, amino acid metabolism, fatty acids metabolism, nucleotide metabolism and choline metabolism pathways, and these differences are tightly associated with their unique biological functions. Our research provided clues and basic information for elucidation of the function of BAT at molecular level.关键词
核磁共振(NMR)/气相色谱(GC)/代谢组学/脂肪酸/棕色脂肪组织(BAT)/白色脂肪组织(WAT)Key words
nuclear magnetic resonance (NMR)/gas chromatography (GC)/metabonomics/fatty acids/brown adipose tissue (BAT)/white adipose tissue (WAT)分类
数理科学引用本文复制引用
宋懿朋,李宁,薛海斯,李晶,王玉兰..棕色脂肪组织和白色脂肪组织的代谢组学研究[J].波谱学杂志,2016,33(2):208-223,16.基金项目
国家自然科学基金资助项目(91439102) （91439102）
