波谱学杂志2016，Vol.33Issue(2)：236-243,8.DOI:10.11938/cjmr20160206
大鼠脑组织含磷代谢物随年龄变化的NMR研究
NMR-Based Analysis of Age-Related Changes of Phosphate Metabolites in Rat Brain
摘要
Abstract
With advances in population aging, age-related diseases have become a global problem. Neurodegenerative disease is one type of leading aging associated diseases, the mechanism of which remains elusive. In the present study,31P NMR spectroscopy was used to characterize alterations of small molecules in rat brain for different age group, and identify alterations of energy associated phosphorylated compounds with aging, which will be helpful for interpreting age-related metabolism in brain. Results showed that energy related metabolite phosphocreatine increased significantly, whereas phosphatidylcholine and phosphorylcholine reduced significantly in aged rat brain. Interestingly, glucose phosphates appeared in aged rat brain. This study demonstrated the alterations of phospholipid metabolism in rat brain with aging, which may help to understand the development of neurodegeneration, and these metabolites may be used as molecular markers for monitoring neurodegenerative disorders.关键词
核磁共振磷谱(31PNMR)/代谢/衰老/脑组织Key words
31P NMR/metabolism/aging/brain分类
数理科学引用本文复制引用
马婧,孙鹏,刘买利,张许,张先荣..大鼠脑组织含磷代谢物随年龄变化的NMR研究[J].波谱学杂志,2016,33(2):236-243,8.基金项目
国家自然科学基金青年基金资助项目(30801207)． （30801207）
