波谱学杂志2016，Vol.33Issue(2)：281-287,7.DOI:10.11938/cjmr20160210
胞苷盐酸盐的质子化位置研究
Positions of Protonation in Cytidine Hydrochloride Revealed by NMR Spectroscopy
摘要
Abstract
Compared to their parent forms of bases or acids,drugs in the form of salts have improved solubility, chemical stability, and capability for recrystallization. For the drug cytidine hydrochloride, whether the protonation position is at N-3 or NH2 remains unclear, and X-ray crystallography cannot provide this information. In this study,1H and13C NMR spectroscopy was used to study the exact protonation position in cytidine hydrochloride. It was shown clearly by chemical shift changes that the protonation position is at N-3 rather than NH2. It was further confirmed that the chemical bond between C-4 and NH2 in cytidine salts has double bond-like properties.关键词
1H NMR/13C NMR/胞苷盐/质子化位置Key words
1H NMR/13C NMR/cytidine hydrochloride/protonation position分类
数理科学引用本文复制引用
王强,李玉江,陶乐,郭晓河,董黎红,宋传君,常俊标..胞苷盐酸盐的质子化位置研究[J].波谱学杂志,2016,33(2):281-287,7.基金项目
国家自然科学基金资助项目(21172202)，河南省重点科技攻关资助项目(152102210379) （21172202）
