南方医科大学学报2016，Vol.36Issue(6)：824-828,5.DOI:10.3969/j.issn.1673-4254.2016.06.16
氯化锂复合磷酸钙骨水泥可促进大鼠胫骨骨缺损修复
Effect of a lithium-doped calcium phosphate cement in promoting tibial bone defect repair in rats
摘要
Abstract
Objective To evaluate the effects a lithium chloride-doped calcium phosphate cement (Li/CPC) on promoting tibial defect repair in rats. Methods Twenty 6-month-old female SD rats randomized into Li/CPC (n=10) and CPC control (n=10) groups. Surgery was performed to create bone defects at the bilateral tibia, which were filled with either of the cement. Five rats from each group were sacrificed at 1 and 2 months after the surgery for micro-CT examination and HE staining of the tibia. Results Micro-CT showed better repair of bone defects in Li/CPC group, which had a significantly higher new bone volume fraction (BV/TV) and a lower trabecular separation/spacing (Tb.Sp) than the control group (P<0.05). HE staining showed an earlier appearance of fiber and osteoid callus in Li/CPC group than CPC control group. The number and quality of bone healing was significantly higher in Li/CPC group than in CPC group. Conclusion Li/CPC possessed better osteoinductivity and can significantly promote bone defect repair in rats.关键词
磷酸钙骨水泥/氯化锂/显微CT/HE染色/骨缺损修复Key words
calcium phosphate cement/lithium chloride/micro-CT/bone defects repair引用本文复制引用
李理,覃永保,马刚,李兵..氯化锂复合磷酸钙骨水泥可促进大鼠胫骨骨缺损修复[J].南方医科大学学报,2016,36(6):824-828,5.基金项目
国家自然科学基金（81260273）；广西自然科学基金（2013GXNSFAA019269） Supported by National Natural Science Foundation of China (81260273) （81260273）
