南方医科大学学报2016，Vol.36Issue(6)：875-879,5.DOI:10.3969/j.issn.1673-4254.2016.06.25
红细胞分布宽度联合脂蛋白相关磷脂酶A2检测可提高冠心病患者的冠状动脉狭窄程度诊断的准确性
Red blood cell distribution width combined with lipoprotein-associated phospholipase A2 detection for improving diagnostic accuracy of coronary artery stenosis in patients with coronary artery disease
摘要
Abstract
Objective To study the association of red blood cell distribution width (RDW) and lipoprotein-associated phospholipase A2 (LP-PLA2) with the degree of coronary artery stenosis in patients with coronary artery disease (CAD) and the value of RDW combined with LP-PLA2 detection in accurate evaluation of coronary artery stenosis. Methods A total of 224 patients including 119 non-CAD cases and 105 CAD cases admitted in our hospital between June, 2013 and June, 2014 were enrolled in this study. The patients' baseline clinical data were collected and venous blood samples were obtained for detecting WBC, RDW-CV and LP-PLA2. The Gensini score of the CAD patients was calculated based on coronary angiographic findings. Results Compared with the non-CAD patients, CAD patients had significantly higher RDW-CV (P=0.009) and LP-PLA2 (P=0.004) levels. The CAD patients with high Gensini scores had also significantly higher RDW-CV (P=0.001) and LP-PLA2 (P<0.001) levels than those with low scores;RDW-CV and LP-PLA2 were significantly correlated with the Gensini score, and the area under curve of their combined detection was 0.931. Conclusion Combination of RDW and LP-PLA2 can improve the diagnostic accuracy of the degree of coronary artery stenosis in patients with CAD.关键词
红细胞分布宽度/脂蛋白相关磷脂酶A2/冠心病/冠状动脉狭窄程度Key words
red blood cell distribution width/lipoprotein-associated phospholipase A2/oronary artery disease/coronary ar-tery stenosis引用本文复制引用
刘季晨,郭凯,卢浩,李梦豪,赖文岩,郭志刚..红细胞分布宽度联合脂蛋白相关磷脂酶A2检测可提高冠心病患者的冠状动脉狭窄程度诊断的准确性[J].南方医科大学学报,2016,36(6):875-879,5.基金项目
广东省产学研项目 （）
