中国耳鼻咽喉头颈外科2016，Vol.23Issue(2)：73-77,5.DOI:10.16066/j.1672-7002.2016.02.004
早期联合鼓室注射糖皮质激素治疗突发性聋效果分析
Efifcacy of early combination treatment with intratympanic glucocorticoid injection for sudden hearing loss
张宇 1高中 1刘亚军 1杨皖菁 1周波 1李丹 1肖键 1王勇1
作者信息
- 1. 湖北医药学院附属东风医院耳鼻咽喉头颈外科，湖北 十堰442000
- 折叠
摘要
Abstract
[ABSTRACT]OBJECTIVETo investigate the therapeutic effect of early combination treatment with intratympanic glucocorticoid injection for sudden sensorineural hearing loss(SSNHL).METHODSTotal of 178 patients with diagnosis of SSNHL, including 44 with hearing loss at middle-low frequencies,50 at high frequencies,44 at all frequencies and 40 at total deafness, were randomly divided into combination treatment group (CT group) and systemic oral prednisone group (OP group).CT group (82 patients) received intratympanic administration of methylprednisolone and oral prednisone in tapering doses. Pure-tone threshold audiometry (PTA) was performed at week 8 after beginning of therapy. RESULTSIn middle-low frequencies, the final PTA and PTA improvement were 26.14±24.82 dB and 42.23±1.61 dB in CT group respectively, and were 37.91±13.98 dB and 30.00±13.30 dB in OP group respectively (both P<0.05). In high frequencies, all frequencies and total deafness SSNHL group, the differences of the final PTA and PTA improvement were not statistically significant in both groups. The PTA improvement in CT group for total deafness (26.52±14.03) dB was more than that of OP group (22.06±11.17)dB (t=2.361,P<0.05). In middle-low frequencies, the recovery rate was 72.73%(16 cases) in CT group, and 40.91% (9 cases) in OP group, the difference was significant (χ2=4.539,P<0.05), but not in apparent effective rate, effective rate and total effective rate. In high frequencies, all frequencies and total deafness, there were no significant differences in therapeutic effect. The recovery rate of total CT group (40.24%) was significantly increased compared with that of OP group (26.04%)(χ2=4.061,P<0.05), the differences of apparent effective rate, effective rate and total effective rate were not statistically significant in both groups.CONCLUSIONFor low-middle frequencies SSNHL, the early combination treatment with intratympanic glucocorticoid injection leads to higher hearing recovery and therapeutic effect compared with traditional oral prednisone. Systemic application should be applied for high frequencies, all frequencies and total deafness of SSNHL.关键词
听觉丧失,突发性/临床方案/糖皮质激素类/听力曲线/鼓室注射/甲泼尼龙琥珀酸钠Key words
Hearing Loss, Sudden/Clinical Protocols/Glucocorticoids/threshold audiogram/intratympanic injection/methylpredinisolone sodium succinate引用本文复制引用
张宇,高中,刘亚军,杨皖菁,周波,李丹,肖键,王勇..早期联合鼓室注射糖皮质激素治疗突发性聋效果分析[J].中国耳鼻咽喉头颈外科,2016,23(2):73-77,5.
