中国耳鼻咽喉头颈外科2016，Vol.23Issue(2)：118-121,4.DOI:10.16066/j.1672-7002.2016.02.015
血清瘦素水平及瘦素受体基因Gln223Arg多态性与阻塞性睡眠呼吸暂停低通气综合征的关系
Relationship of levels of Leptin and Leptin receptor gene Gln223Arg in patients with obstructive sleep apnea hypopnea syndrome
韩林华 1刘晨 2王红阳 2王亚囡2
作者信息
- 1. 华北理工大学附属开滦总医院林西医院呼吸内科，河北 唐山063103
- 2. 华北理工大学附属医院呼吸内科，河北 唐山063000
- 折叠
摘要
Abstract
[ABSTRACT]OBJECTIVETo compare the difference of serum Leptin between obstructive sleep apnea hypopnea syndrome (OSAHS) patients and the control group, to analyze the genotype distribution and allele frequency of Leptin receptor gene Gln223Arg in OSAHS patients. To discuss the relationship between the gene polymorphism and OSAHS susceptibility.METHODSOSAHS group(221 cases) and control group (213 cases) were divided into obese OSAHS group (107 cases), non-obese OSAHS group (114 cases), obese control group (110 patients) and normal control group (103 cases). All participants were tested the level of serum Leptin after monitoring by polysomnography (PSG). The genomic DNA of Leptin receptor gene was extracted and the genotype was analyzed.RESULTSThe level of serum Leptin in non-obese OSAHS patients was 13.59±5.01μg/L and (13.10±1.87)μg/L in obese control patients. They were higher than that in normal control group, but there were no significant difference among them. The level of Leptin in obese OSAHS group was(19.01±3.43)μg/L, that was significantly higher than that in other three groups. Leptin receptor gene Gln223Arg genotype and allele frequency had no significant difference among the 4 groups. But neck circumference of GG genotype patients was greater than that of AA/AG patients.CONCLUSIONThe level of serum Leptin in obese OSAHS patients is significantly higher than that in control group. There is no relations between the gene polymorphism of two sites in Leptin receptor gene Gln223Arg and the onset of OSAHS. But Gln223Arg variation may be involved in regulating the OSAHS patients' neck fat distribution.关键词
睡眠呼吸暂停,阻塞性/瘦素/病例对照研究Key words
Sleep Apnea, Obstructive/Leptin/Case-Control Studies引用本文复制引用
韩林华,刘晨,王红阳,王亚囡..血清瘦素水平及瘦素受体基因Gln223Arg多态性与阻塞性睡眠呼吸暂停低通气综合征的关系[J].中国耳鼻咽喉头颈外科,2016,23(2):118-121,4.
