中国耳鼻咽喉头颈外科2016，Vol.23Issue(6)：331-334,4.DOI:10.16066/j.1672-7002.2016.06.007
听觉传导通路下丘区域特异性蛋白分析
Analysis of inferior colliculus region typical proteins in auditory pathway
摘要
Abstract
OBJECTIVE To study the proteome of inferior colliculus and determinate the region-typical proteins which may be the candidate cause of the Central Auditory Processing Disorders. METHODS The telencephalon was taken as reference, and then identified and quantified the proteome of IC of adult rats with iTRAQ. Those with higher abundance in inferior colliculus than the other three regions were considered as IC-Region typical proteins,which may lead to functional specializations. RESULTS We identified 1937 cytomembrane proteins in total, among which there are 53 IC-Region typical proteins, which may lead to functional specializations of inferior colliculus.We used GO and KEGG pathway to analyze these proteins and then found that these proteins mainly take part in the regulation of neurons development and information integrations. CONCLUSION Our quantitative comparison of inferior colliculus has revealed two candidate proteins, including CaMKII and SV2A, which may play important roles in maintaining the balance of excitatory and inhibitory transmitters release. These proteins may be the candidate proteins for Central Auditory Processing Disorders.关键词
蛋白质组学/下丘/中枢听觉处理/同位素标记相对和绝对定量Key words
Proteomics/Inferior Colliculus/central auditory processing/isobaric tags for relative and absolute quantitation引用本文复制引用
李宛桐,徐莹,李晓璐..听觉传导通路下丘区域特异性蛋白分析[J].中国耳鼻咽喉头颈外科,2016,23(6):331-334,4.基金项目
江苏省“科教兴卫工程”医学重点人才（RC2011073）、江苏省科技厅国际合作项目（BZ2011043）和江苏省人力资源和社会保障厅“六大人才高峰”（2009075）联合资助 （）
