中国耳鼻咽喉头颈外科2016，Vol.23Issue(6)：349-352,4.DOI:10.16066/j.1672-7002.2016.06.012
Maspin在侵袭型真菌性鼻-鼻窦炎中表达的研究
Expression of Maspin in invasive fungal rhinosinusitis
虞和伟 1康宗辉 2潘丹 3夏思文 2胡献惠 2陈英武 1何云生 1黄益灯2
作者信息
- 1. 浙江省湖州市中心医院耳鼻咽喉科，浙江 湖州 313000
- 2. 解放军第一一八医院耳鼻咽喉头颈外科，浙江 温州 325000
- 3. 温州市人民医院病理科，浙江 温州 325000
- 折叠
摘要
Abstract
OBJECTIVE To explore the expression of Maspin in invasive fungal rhinosinusitis (IFRS) and the value of Maspin in the diagnosis of IFRS. METHODS Forty two cases of fungal rhinosinusitis (FRS) were set as the experimental group, which included 12 cases of IFRS and 30 cases of noninvasive fungal rhino-sinusitis (NIFRS). At the same time, 30 cases of chronic rhino-sinusitis were set as control group. Immunohistochemistry (IHC) was used to detect the expression of Maspin. RESULTS Compared with the control group, the expression of Maspin in FRS group decreased statistically (t=-3.367, P<0.05). The IFRS group, compared with other two groups, had the lowest expression of Maspin (t=-3.390, P<0.05; t=-4.143, P<0.05). By using Maspin score of 5.70 as the cut-off point, the sensitivity and specificity for the diagnosis of IFRS was 91.7% and 88.3% respectively. CONCLUSION The expression of Maspin is very low in IFRS group. Down-regulation of Maspin expression may be a potential indicator for diagnosis of IFRS.关键词
免疫组织化学/真菌病/鼻窦炎/侵袭性/MaspinKey words
Immunohistochemistry/Mycoses/Sinusitis/invasive/Maspin引用本文复制引用
虞和伟,康宗辉,潘丹,夏思文,胡献惠,陈英武,何云生,黄益灯..Maspin在侵袭型真菌性鼻-鼻窦炎中表达的研究[J].中国耳鼻咽喉头颈外科,2016,23(6):349-352,4.
