中国耳鼻咽喉头颈外科2016，Vol.23Issue(6)：353-356,4.DOI:10.16066/j.1672-7002.2016.06.013
重组人表皮生长因子对鼻-鼻窦炎患者鼻内镜术后创面上皮化的影响
Effects of recombinant human epidermal growth factor on wound healing after endoscopic sinus surgery
摘要
Abstract
OBJECTIVE To investigate the effects of recombinant human epidermal growth factor (rhEGF) on wound healing of chronic sinusitis patients after functional endoscopic sinus surgery. METHODS A total of 110 patients with chronic sinusitis underwent functional endoscopic sinus surgery with both sides of their nose. The right side of their nasal cavity (control group) treated by nasal irrigation and steroid nasal spray, the left side of their nasal cavity (study group) treated by nasal irrigation and the nasal spray of steroid hormones and rhEGF. Surgical effect was evaluated under nasal endoscope at 2, 4, 12 and 24 weeks after surgery, while subjective symptom was evaluated depending on visual analogue scale (VAS). Both the score of endoscopic examination and VAS, also the rates of epithelization of the two groups were compared. RESULTS The score of endoscopic examination of the study group at 2 weeks after surgery was better than that of the control group, which had statistical significance, while the score of VAS had no statistical difference. The score of endoscopic examination and VAS, the rate of epithelization in study group at 4 and 12 weeks after surgery were better than those in control group, and the difference was statistically significant, but they were no statistical difference at 24 weeks after surgery. CONCLUSION The using of rhEGF nasal spray on chronic sinusitis patients with functional endoscopic sinus surgery can shorten the time of epithelization, improve the situation of nasal mucosa and patients' subjective symptoms, it is worthy of clinical application.关键词
内窥镜检查/鼻窦炎/重组人表皮生长因子/上皮化Key words
Endoscopy/Sinusitis/recombinant human epidermal growth factor/epithelization引用本文复制引用
何观文,朱忠寿,魏日富,程道俊,李慧凤..重组人表皮生长因子对鼻-鼻窦炎患者鼻内镜术后创面上皮化的影响[J].中国耳鼻咽喉头颈外科,2016,23(6):353-356,4.基金项目
宁德市科技局科研计划项目资助 （）
