解放军医药杂志2016，Vol.28Issue(5)：44-47,53,5.DOI:10.3969/j.issn.2095-140X.2016.05.011
HIF-α、VEGF 和 DLL4在非小细胞肺癌中的表达及临床意义
Expressions and Clinical Significance of HIF-α,VEGF and DLL4 in Non-small Cell Lung Cancer
摘要
Abstract
Objective To investigate the expressions and clinical significance of delta-like ligand 4( DLL4), Hypoxia inducible factor alpha(HIF-α)and Vascular endothelial growth factor( VEGF)in non-small cell lung cancer (NSCLC). Methods A total of 72 samples of NSCLC patients undergoing surgery during October 2012 and November 2015 were chosen as NSCLC group,and 72 pulmonic tissue samples more than 5 centimeters away from of the primary tumor,which were confirmed with no tumor invasion by hematoxylin and eosin stain(HE)staining,were chosen as con-trol group. The expressions of DLL4,HIF-α and VEGF were detected using immunohistochemical staining method,and were analyzed,combined with the pathological data. Results The positive expression rates of DLL4,HIF-α and VEGF in NSCLC group were significantly higher than those in control group(P ﹤ 0. 01). The expressions of DLL4,HIF-α and VEGF related to degrees of tumor differentiation,clinical stages and lymph node metastasis(P ﹤ 0. 05),but the expres-sions were not related to patients’ age,gender,pathological types and tumor diameter( P ﹥ 0. 05). The expressions of DLL4,HIF-α and VEGF showed significant positive relation between every two(r = 0. 320,0. 366,0. 335,P ﹤ 0. 01). Conclusion DLL4,HIF-α and VEGF may play a collaborative role in incidence,development and metastasis of NSCLC. It has some value for judging incidence,development and prognosis of NSCLC and studying new targeted thera-peutic drugs by detecting the expressions of DLL4,HIF-α and VEGF.关键词
癌,非小细胞肺/Delta样配体4/低氧诱导因子α/血管内皮生长因子/基因表达调控,肿瘤Key words
Carcinoma,non-small cell lung/Delta-like ligand 4/Hypoxia inducible factor alpha/Vascular en-dothelial growth factor alpha/Gene expression regulation,neoplastic分类
医药卫生引用本文复制引用
王维,李强,韩青松,池菲,黄文峰..HIF-α、VEGF 和 DLL4在非小细胞肺癌中的表达及临床意义[J].解放军医药杂志,2016,28(5):44-47,53,5.基金项目
河北省卫生厅科研基金项目 （）
