河北医学2016，Vol.22Issue(5)：714-716,3.DOI:10.3969/j.issn.1006-6233.2016.05.004
microRNA－1与microRNA－126在支气管哮喘急性发作期患儿外周血中的表达及诊断价值
The Expression of microRNA-1 and microRNA-126 in Peripheral Blood of Asthmatic Children with Acute Episode of Bronchial Asthma and its Correlation with the Onset of the Disease
摘要
Abstract
Objective:To investigate the expression of microRNA-1 and microRNA-126 in peripheral blood in children with acute episode of bronchial asthma and its correlation with the onset of the disease. Methods:48 patients with acute exacerbation of bronchial asthma in our hospital from Jan. 2013 to Jan. 2015 were included in the asthma group, while the control group was included 52 cases of healthy children. The pe-ripheral blood of the two groups were collected, and the level of microRNA-126 and microRNA-1 was detec-ted, and the levels of IL-4 and INF-γwere detected as the same time. Results:The levels of IL-4,INF-γin asthma group were (109.65±74.31)ng/L and (70.47±11.96)ng/L, while those in control group were (78.47 ±75.78)ng/L and(77.05±17.21)ng/L, the difference was significant (P < 0.05). The levels of microRNA-1,microRNA-126 in asthma group were(2.15±0.97) and(7.34±1.26), the levels of microRNA-1,microR-NA-126 in control group were(5.81±1.29) and(3.66±0.91), the difference was significant (P <0.05). The sensitivity and specificity of microRNA-126 and microRNA-1 in peripheral blood of children with acute attack of bronchial asthma were 85.42%, 78.85%, 79.17% and 73.08% respectively, and the area under the ROC curve was 0.917 and 0.865 respectively. Conclusion:The level of microRNA-126 in peripheral blood of asth-matic children with acute attack of bronchial asthma is increased, and the level of microRNA-1 is deereased, and both can be used as an objective indicator of acute attack of bronchial asthma in children.关键词
microRNA-1/microRNA-126/支气管哮喘急性发作/相关性Key words
microRNA-1/microRNA-126/Acute attack of bronchial asthma/Correlation引用本文复制引用
颜世军,潘秋莎,周炳文,孙雨..microRNA－1与microRNA－126在支气管哮喘急性发作期患儿外周血中的表达及诊断价值[J].河北医学,2016,22(5):714-716,3.基金项目
江苏省高等教育教改研究立项课题，(编号:2013JSJG037) （编号:2013JSJG037）
