河北医学2016，Vol.22Issue(5)：727-730,4.DOI:10.3969/j.issn.1006-6233.2016.05.009
血糖波动与2型糖尿病患者周围神经病变的相关性研究
The Correlation Analysis between Glucose Fluctuation and Diabetic Peripheral Neuropathy in Type 2 Diabetic Patients
摘要
Abstract
Objective:To investigate the relationship between blood glucose fluctuation and peripheral neuropathy in patients with type 2 diabetes mellitus. Methods:According to their peripheral nerve conduction velocity, a total of 112 T2DM patients were divided into two groups: the norma group ( DM) and abnormal group ( DPN) . All the 2 diabetic patients were observed by continuous glucose monitoring system ( CGMS) for 72 hours. The mean blood glucose ( MBG) , standard deviation ( S) , largest amplitude of glycemic excursions (CV), mean amplitude of glycemic excursions (MAGE) and absolute means of daily differences (MODD) were calculated in all the patients, with determination of blood HbA1c, glucose, lipids and BP of each indi-vidual. Results:There were significant differences in the course of disease, HbA1C, TG, SBP, coefficient of glucose variablity ( CV) , mean amplitude of glucemic excursions ( MAGE) , mean blood glucose( MBG) and standard deviation ( SD) between the two groups( P<0.05) . Logistic regression analysis showed that the course of disease, CV and MAGE were the independent risk factors for peripheral nerve conduction velocity ( P<0. 05) . Conclusion:Glucose fluctuation is a independent risk factor in the development of DPN in type 2 diabet-ic patients. Glycemic excursion should be avoided during the blood control.关键词
2型糖尿病/周围神经病变/血糖波动Key words
Type 2 diabetic/Peripheral nerve lesion/Glucose fluctuation引用本文复制引用
王晓薇..血糖波动与2型糖尿病患者周围神经病变的相关性研究[J].河北医学,2016,22(5):727-730,4.基金项目
2014年上海市青浦区科学技术发展基金项目，(编号:青科发2014－16) （编号:青科发2014－16）
