湖南中医药大学学报2016，Vol.36Issue(6)：16-19,4.DOI:10.3969/j.issn.1674-070X.2016.06.005
柴胡三参胶囊对缺血性心律失常大鼠模型心肌细胞HERG K+通道蛋白的研究
Effect of Chaihu Sanshen Capsule on Myocardial Cell HERG K+ Channel Protein in Ischemic Arrhythmia Rat Models
摘要
Abstract
Objective To investigate Chaihu Sanshen capsule on myocardial ischemic arrhythmia mice HERG K +channel protein expression in ischemic arrhythmia rat models, and provide more experimental basis for clinical use of Chaihu Sanshen capsule. Methods The rats were randomly divided into blank group, sham-operation group, model group, Chaihu Sanshen (Qinghao) group, Chaihu Sanshen (Changshan) group, Wenxin granule group, amiodarone group, 10 rats in each group. The drug group was given pretreatment for 10 days before 10 days of left anterior descending coronary artery. The change of electrocardiogram and myocardial HERG K + channel protein expression in left anterior descending coronary artery was observed. Results Chaihu Sanshen capsule can reduce the incidence of ischemic arrhythmias (P<0.05), and significantly reduce the HERG K+ channel protein inactivation (P<0.01). Conclusion The antiarrhythmic effect of Chaihu Sanshen capsules is obvious, and its targets are HERG K+ channel proteins.关键词
柴胡三参胶囊/缺血性心律失常/HERG K+Key words
Chaihu Sanshen capsule/ischemic arrhythmias/HERG K+分类
医药卫生引用本文复制引用
刘建和,杨成龙,苏联军,周正,刘锦霞,唐银,胡志希,王建国..柴胡三参胶囊对缺血性心律失常大鼠模型心肌细胞HERG K+通道蛋白的研究[J].湖南中医药大学学报,2016,36(6):16-19,4.基金项目
湖南省科技厅科研项目（2013SK3103）；湖南省中医药管理局重点课题（201303）；湖南省重点实验室开放基金计划项目（2014XN-FZ03）；湖南省科技创新项目投资计划（[2014]658）；2015年湖南省学位与研究生教育教改研究课题（JG2015B071）。 （）
