湖南中医药大学学报2016，Vol.36Issue(6)：29-32,4.DOI:10.3969/j.issn.1674-070X.2016.06.008
灰质异位的临床病理学特征研究
Clinical Pathological Features of Gray Matter Heterotopias
冷慧 1付静 1梁乐 1刘瑛1
作者信息
- 1. 北京市海淀医院，北京大学第三医院海淀院区，北京 100080
- 折叠
摘要
Abstract
Objective To explore the objective basis for the pathological diagnosis of gray matter heterotopia. Methods The pathological and clinical data of 17 cases of gray matter heterotopia resection were analyzed, and supplemented by immunohistochemical method, the number and types of neurons in the gray matter heterotopia were counted. Results Only 3 cases of gray matter heterotopias were diagnosed by MRI before surgery in this group. The remaining 14 cases (82.4%, 14/17) were all diagnosed by microscopic diagnosis. There are three types of gross performance: (1) isolated gray matter nodule in white matter. (2) Gray matter heterotopia is located in the subcortical and show nodular or tongue connected to the cortex. (3) Cerebral cortical is thickening. The boundary is not clear between gray matter and white matter. Microscopically, the boundary of some heterotopic gray matter is clear,neuronal arrangement disorder within the heterotopic gray matter,polarity of dendrite and axon are disorder. There isn't normal cortical layer structure. Neurons show degenerative changes, necrosis and immature forms. Immunohistochemistry GFAP can show the outline of some gray matter heterotopic nodules. NeuN and Map-2 staining showed a decrease in the number of neurons and a increase in proportion of immature neurons. The difference was statistically significant (t=-3.66,P<0.01). Conclusion A wide range of gray matter lesions can be found in imaging detection, But most of the heterotopia diagnosis still depends on pathology. GFAP is valuable for the observation of the shape of the gray matter heterotopias. Counting NeuN and Map-2 positive cells can provide basis for the diagnosis of gray matter heterotopia.关键词
灰质异位/病理学/免疫组化Key words
gray matter heterotopia/pathology/immunohistochemistry分类
医药卫生引用本文复制引用
冷慧,付静,梁乐,刘瑛..灰质异位的临床病理学特征研究[J].湖南中医药大学学报,2016,36(6):29-32,4.
