湖南中医药大学学报2016，Vol.36Issue(6)：38-42,5.DOI:10.3969/j.issn.1674-070X.2016.06.010
马归液对腺性膀胱炎大鼠膀胱组织Bcl-2、Bax表达的影响
Effect of Magui Liquid on the Expression of Bcl-2 and Bax in Bladder Tissue of Rats with Cystitis Glandularis
摘要
Abstract
Objective To observe the effect of Magui liquid on bladder tissues in rats with cystitis glandularis, and to provide the experimental basis and theoretical basis for the treatment of cystitis glandularis. Methods Firstly, the model rats with cystitis glandularis were successfully established by bladder instillation of Escherichia coli. The successful model rats were given Magui liquid (group 1: once a week; group 2: twice a week), pirarubicin and physiological saline for eight weeks. Then, the bladder tissues of rats in each group were given pathological examination and electron microscopy assay, and the Bcl-2, Bax expressions were detected. The changes of the structure of bladder mucosa in rats were detected. Results After the perfusion of Magui liquid, the pathological examination of Magui liquild groups showed that the bladder tissue had no inflammatory disease. Compared with the physiological saline group, the Bax and Bcl-2 gray mean were statistically significant (P<0.05), the diffrences between Magui liquild groups were not statistically significant (P>0.05). Compared with pirarubicin and physiological saline group, the Bcl-2/Bax in Magui liquild groups was statistically significant (P<0.05), the Bcl-2/Bax between Magui liquid groups has no statistically significant (P>0.05). Conclusion Magui liquild shows obvious effect and repair functioon on the glandular cystitis bladder mucosa of rats, and the rats with best curative effect are given perfusion for two times a week.关键词
腺性膀胱炎/大鼠/马归液/Bcl-2/BaxKey words
cystitis glandularis/rats/Magui liquild/Bcl-2/Bax分类
医药卫生引用本文复制引用
蔡蔚,谢海平,龙蠡,谢晓,杨华伟..马归液对腺性膀胱炎大鼠膀胱组织Bcl-2、Bax表达的影响[J].湖南中医药大学学报,2016,36(6):38-42,5.基金项目
湖南省自然科学基金项目（13JJ5029）；湖南省教育厅优秀青年项目（15B175）。 （）
