湖南中医药大学学报2016，Vol.36Issue(6)：43-46,4.DOI:10.3969/j.issn.1674-070X.2016.06.011
中药杜仲-牛膝配伍对去卵巢大鼠骨质疏松症的干预实验研究
Influence of TCM Eucommia-Achyranthes Compatibility on Osteoporosis in Ovariectomized Rats
摘要
Abstract
〔Abstract〕 Objective To investigate the interventional effect of Eucommia-Achyranthes compatibility on osteoporosis in ovariectomized rats. Methods Eighty-four rats were randomly divided into normal control group (n=12), sham-operation group (n=12), and the remaining 60 rats after the success of the modeling were randomly divided into model group, positive control group (group afar ossification alcohol), eucommia bark group, achyranthes group, eucommia-achyranthes group, 12 rats in each group. After given medicine for 3 months, the serum estradiol (E2), calcium ion, phosphate ion, alkaline phosphatase and the bone mineral density (BMD) were detected. Results Compared with normal control group, the serum E2, calcium ion, phosphate ion and bone mineral density of model group were significantly lower than normal control group (P<0.01), and the alkaline phosphatase in serum was more higher (P <0.05). Compared with the model group, the content of E2 in achyranthes group and eucommia-achyranthes group was increased obviously (P<0.05), the BMD and serum calcium ion, phosphate ion in eucommia bark group, achyranthes group, eucommia-achyranthes group, postive control group were increased obviously (P<0.01), and the alkaline phosphatase in the groups were reduced significantly (P<0.05). The alkaline phosphatase of eucommia-achyranthes group was lower than that in eucommia bark group and achyranthes group (P<0.05). Conclusion The compatability of Eucommia-Achyranthes shows increasing trend in anti-osteoporosis, and its effect may be related to increasingserum calcium, phosphorus, improving BMD.关键词
杜仲-牛膝药对/骨质疏松症/雌二醇/骨密度/去卵巢大鼠/杜仲/牛膝Key words
couplet medicine of Eucommia-Achyranthes/osteoporosis/estradio/bone mineral density/ovariectomized rats/eucommia bark/Achyranthes bidentata分类
医药卫生引用本文复制引用
高卫辉,向艳华,刘云,邓桂明,林洁,林王森枝,贺瑶..中药杜仲-牛膝配伍对去卵巢大鼠骨质疏松症的干预实验研究[J].湖南中医药大学学报,2016,36(6):43-46,4.基金项目
湖南省科学技术厅科技计划项目（2012FJ4287）。 （）
