吉林大学学报（理学版）2016，Vol.54Issue(3)：652-656,5.DOI:10.13413/j.cnki.jdxblxb.2016.03.43
药食同源植物醛糖还原酶抑制剂的筛选
Screening of ARI from Medicinal and Edible Plant
摘要
Abstract
According to the mechanism of disease of diabetic complication,we selected 50 kinds of medicinal and edible plants,and screened containing effective natural ingredients of aldose reductase inhibitors (ARI).By measuring the IC50 value as a reference,we compared the samples known to inhibit the activity of ARI efficiency in plants.The results show that the ARI activity of lemon,balsam pear,plum and pomegranate are strong.Their IC5 0 values are 0.74,0.64,0.2 5 ,0.02 7 mg/mL.关键词
药食同源/植物/糖尿病并发症/醛糖还原酶抑制剂Key words
drug and food source/plant/diabetic complication/aldose reductase inhibitor分类
医药卫生引用本文复制引用
王立成,张鹏,徐佳,刘雨婷,金萍,王琪菲,修志明,张越,王丽萍..药食同源植物醛糖还原酶抑制剂的筛选[J].吉林大学学报（理学版）,2016,54(3):652-656,5.基金项目
吉林省自然科学基金(批准号:201015171)、吉林省医药产业发展专项基金(批准号:YYZX201150-2)、吉林省科技发展计划项目(批准号:201205017)和吉林大学大学生创新基金(批准号:2014A34116) （批准号:201015171）
