昆明医科大学学报2016，Vol.37Issue(5)：5-8,4.
云南汉族人群TNF-α基因和ALCAM 基因多态性与HCV 慢性感染的相关性
Association Study of TNF-αand ALCAM Polymorphisms with Chronic HCV Infection in Yunnan Han Population
摘要
Abstract
Objective To discuss the association of allele polymorphisms SNP-rs1799724(C>T)in the TNF-αand SNP-rs11559013(G>A)in the ALCAM with HCV chronic infection in Han population in Yunnan province. Methods 434 HCV chronic infectious patients and 444 healthy individuals of Han Chinese population in Yunnan province were recruited. Two single nucleotide polymorphisms(SNPs)in the SNP-rs1799724(C>T) of TNF-αgene and SNP-rs11559013(G>A)of ALCAM gene were determined by real-time TaqMan polymerase chain reaction. We evaluated the associations of the two SNPs with HCV chronic infection. Results The distributions of allele and genotype of SNP-rs1799724(C>T)in the TNF-αand SNP-rs11559013(G>A)in the ALCAM between hepatitis C virus(HCV)chronic infectious patients and the healthy controls were not statistically significant(P > 0.05). Conclusion SNP-rs1799724(C>T)in the TNF-αand SNP-rs11559013(G>A) in the ALCAM have no association with HCV chronic infection in the Han population in Yunnan province.关键词
HCV/慢性感染/单核苷酸多态性/TNF-α/ALCAMKey words
HCV/Chronic infection/SNPs/TNF-α/ALCAM分类
医药卫生引用本文复制引用
刘城秀,沈云松,张禹,檀林萍,姚月婷,俞建昆,李桃意,姚宇峰,史荔..云南汉族人群TNF-α基因和ALCAM 基因多态性与HCV 慢性感染的相关性[J].昆明医科大学学报,2016,37(5):5-8,4.基金项目
国家自然科学基金资助项目（81160197）；吴阶平医学基金资助项目 （）
