昆明医科大学学报2016，Vol.37Issue(5)：42-45,4.
云南彝族男性AT1R A1166C、AGT M235T多态性及血生化指标与原发性高血压的相关性
The Correlation of Polymorphisms of AT1R A1166C and AGT M235T Genes and Blood Biochemical Indicators with Essential Hypertension in the Male of Yi Nationality in Yunnan Province
摘要
Abstract
Objective To investigate the correlation of the polymorphisms of angiotensin Ⅱtype 1 receptor (AT1R)gene A1166C and angiotensinogen(AGT)gene M235T and blood biochemical indicators with essential hypertension(EH)in the male of Yi nationality in Yunnan province. Methods 92 hypertensive and 70 normotensive of Yi people were recruited in Yunnan province. Their basic information and blood biochemical indicators were obtained by questionnaire and standardized physical examination. The genes polymorphisms were determined by polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)technique. Results(1)For the male EH patients of Yi nationality,1166C and 235T allele frequencies were 0.038 and 0.772. No significant differences in allele frequency or genotype frequency were observed between the two groups(P > 0.05).(2)The levels of TC,LDL-C and TG in EH were significantly higher than those in controls(P < 0.05). Conclusion The AT1R A1166C and AGT M235T polymorphisms were not related to the pathogenesis of EH in the male of Yi people. However,the high levels of TC,TG and LDL-C might be the risk factors of EH.关键词
原发性高血压/遗传多态性/血生化指标/彝族男性Key words
Essential hypertension/Genetic polymorphism/Blood biochemical indicator/Male of Yi Nationality分类
医药卫生引用本文复制引用
罗兰,何永蜀,陈元晓,龙莉,沈兰,杨榆玲..云南彝族男性AT1R A1166C、AGT M235T多态性及血生化指标与原发性高血压的相关性[J].昆明医科大学学报,2016,37(5):42-45,4.基金项目
云南省科技厅-昆明医科大学应用基础研究联合专项基金资助项目（2014F Z 004）；云南省教育厅科学研究基金资助项目 （）
