临床口腔医学杂志2016，Vol.32Issue(6)：326-328,3.DOI:10.3969/j.issn.1003-1634.2016.06.003
OSCC患者瘦素水平测定及其临床意义的研究
The levels of salivary and serum leptin in patients with oral squamous cell carcinoma and their potential clini-cal significance
熊磊 1代婧 1唐祎1
作者信息
- 1. 荆州市中心医院 湖北 荆州 434020
- 折叠
摘要
Abstract
Objective:The purposes of the present study are to assess the expression levels of leptin in serum and salivary in patients with squamous cell carcinoma (OSCC). Method:Enrolled participants in this study included 50 patients with OS-CC and 40 healthy volunteers. Serum and salivary leptin levels were measured via enzyme-linked immunosorbent assay (ELISA) method. Result:A significant down-regulation of leptin in salivary and serum in OSCC was found when compared with control subjects. Moreover, a significant correlation was shown between serum and salivary leptin levels, body mass in-dex and various histopathological and TNM (tumour nodes metastasis) staging variants of OSCC. In addition, a highly signifi-cant correlation was shown between salivary and serum leptin levels in both groups.Conclusion:The results of this study demonstrate a potential mechanism of salivary and serum leptin levels in OSCC. Serum and salivary leptin may play a key role in OSCC.关键词
口腔鳞状细胞癌/唾液/血液/瘦素/恶病质Key words
Squamous cell carcinoma/Salivary/Serum/Leptin/Cachexia分类
医药卫生引用本文复制引用
熊磊,代婧,唐祎..OSCC患者瘦素水平测定及其临床意义的研究[J].临床口腔医学杂志,2016,32(6):326-328,3.
