摘要
Abstract
Objective To analyze literatures about drug -induced death caused by cephalosporins,investigate the char-acteristics of drug -induced deaths by cephalosporins and provide a scientific basis for drug safety.Methods To retrieve lit-eratures related cephalosporins cause drug -induced death in China knowledge Reseurce Integrated Database,Wanfang Data and VIP Network,and retrospectively analysis by sex,age,clinical manifestations of adverse drug reactions and cause of death and other information.Results There were 55 effective documents of 76 cases,45 males (59.2%),31 females (40.8%), and the ratio was 1 .45∶1 ;Patients aged 0.5 to 79 years,the mean age was 46.9 ±17.9.Patients with primary disease 29 cases of upper respiratory tract infection (38.2%),12 cases of tracheitis(bronchitis)(15.8%),lung infection in 11 patients (14.5%), and other respiratory diseases mainly with intravenous administration of Lord,there were 65 cases (85.5%).ADR occurrence time,mainly within 10 min,there were 48 cases (63.2%);59 cases of anaphylactic shock patients (77.6%)occurred in patients of all ADR,shock symptoms occur after administration time <5 minutes,46 patients (78.0%).Highest third -generation cepha-losporin usage,there were 49 cases(64.5%);The most frequently used before 5 cephalosporins were:ceftriaxone,cefazolin,cef-operazone,cefotaxime sodium,cefoperazone -sulbactam.Clinical manifestations of adverse reactions in all patients and cause of death distribution,accounting for up to anaphylactic shock 59 cases (77.6%).Conclusion The clinical application of antibiotics was widespread,the clinical manifestations of ADR were different,and the main cause of the death of drug was allergic shock,and the use of the third generation of the most important was the highest.In the process of clinical medication,the medical history,al-lergic history,etc.,should be closely observed to prevent the occurrence of ADR fatal cases.关键词
头孢菌素/药源性死亡/文献调查Key words
Cephalosporins/Drug induced death/Literature survey分类
医药卫生
