现代检验医学杂志2016，Vol.31Issue(3)：55-58,4.DOI:10.3969/j.issn.1671-7414.2016.03.015
白藜芦醇对金黄色葡萄球菌标准株抑菌作用及超微结构的影响
Antibacterial and Ultrastructure Effect of RES on Staphylococcus Aureus Standard Strains ATCC 2 5 9 2 3
摘要
Abstract
Objective To study the antibacterial effect and mechanism of Resveratrol(RES)on Staphylococcus aureus stand-ard strains (ATCC 25923).Methods Using the microdilution protocol,to obtain minimal inhibitory concentrations(MIC)of RES on Staphylococcusaureus standard strains.Transmission electron microscope (TEM)and scanning electron microscope (SEM)were tested to obtain the effect of Staphylococcusaureus on Ultrastructure.Results The MIC of RES to Staphylo-coccusaureus standard strains ATCC 25923 were 0.256 mg/ml.Compared with control group,transmission electron and scanning electron microscope observation showed that after the act of RES on S.au standard strains,the cell morphology of S.au standard strains changed serious deformation,cells in all shapes and size,cell boundary roughness,cell wall defected and ruptured,and osteoporosis of edgeo,looseness of its structure,the nuclear membrane rupture,local showed vacuolar characteristics.Cell ultrastructure was obvious damaged and inhibition.Conclusion Rseveratrol had obvious inhibition and destruction to the standard strains of staphylococcus aureus,and the inhibition mechanism may be related to the destruction of cell membrane permeability.关键词
白藜芦醇/金黄色葡萄球菌/抑菌机制/电镜Key words
resveratrol/staphylococcus aureus/antibacterial mechanism/electron microscope分类
医药卫生引用本文复制引用
王鑫,张瑞,李雅静,董倩倩..白藜芦醇对金黄色葡萄球菌标准株抑菌作用及超微结构的影响[J].现代检验医学杂志,2016,31(3):55-58,4.基金项目
河北省2015年医学科学重点研究课题，编号20150259。 （）
