现代检验医学杂志2016，Vol.31Issue(3)：65-68,4.DOI:10.3969/j.issn.1671-7414.2016.03.018
血清脂蛋白（a）和同型半胱氨酸（HCY）与2型糖尿病胰岛素抵抗的临床研究
Clinical Study of Serum Lipoprotein(a) and Homocysteine with Type 2 Diabetes Mellitus and Insulin Resistance
摘要
Abstract
Objective To analyze the levels of serum lipoprotein (a)[Lp(a)]and homocysteine (CHY)in type 2 diabetes mellitus (T2DM)patients and todetermine the relationship between them and diabetic insulin resistance.Methods A total of 108 patients with T2DM and 50 healthy volunteers (control group)were studied.T2DM group according to the presence of kidney disease complications could be divided into simple diabetes group (SDM)in 48 patients with diabetic nephropathy (DN)group of 60 cases.Collected patients general data and determined two groups of glycosylated hemoglobin (HbA1c), low density lipoprotein (LDL),urea nitrogen (BUN),serum creatinine (SCr),urinary inhibition C (CysC),Lp(a)and HCY levels;Compared differences between groups and how they related to T2DM kidney disease,and the relationship between in-sulin resistance.Results ①Compared between three groups only the weight (NC group 60.1±10.34 kg,SDM group 67.2 ±11.38 kg,DN group 68.8±1.35 kg),the difference was statistically significant (F=0.457,P=0.035).②compared be-tween the three groups,the levels of HbA1c (F=3.421,P=0.013),LDL-C (F=2.963,P=0.041),BUN (F=4.637,P=0.031),SCr (F=2.369,P=0.024),CysC (F=3.697,P=0.011),Lp(a)(F=1.236,P=0.021),HCY (F=4.317,P=0.027)were increased significantly.③FPG,FINS and HOMA-IR in SDM group were 5.99±0.94 mmol/L,61.11±28.46 pmol/L and 2.93±1.97 respectively,FPG,FINS and HOMA-IR in DN group were 9.01±2.23 mmol/L,98.56±62.14 pmol/L and 4.34±2.74 respectively.Compared between the two groups,FPG (t=0.47,P=0.017),FINS (t=0.55,P=0.039),HOMA-IR (t=0.69,P=0.024)differences were statistical significance.④The Lp(a),HCY were significantly pos-itive correlation with HOMA-IR (r=0.761,P=0.044;r=0.840,P=0.021).Conclusion Lp(a)and HCY levels in serum associated with diabetic nephropathy,and insulin resistance.And the detection of serum Lp(a)and HCY has important sig-nificance for early detection of diabetic nephropathy.关键词
脂蛋白(a)/同型半胱氨酸/2 型糖尿病/胰岛素抵抗Key words
lipoprotein (a)/homocysteine/type 2 diabetes mellitus/insulin resistance分类
医药卫生引用本文复制引用
余安运,刘夏炎,宋煜,于佩方..血清脂蛋白（a）和同型半胱氨酸（HCY）与2型糖尿病胰岛素抵抗的临床研究[J].现代检验医学杂志,2016,31(3):65-68,4.基金项目
陕西省科技攻关项目［批准号2008K16-6（7）］。 （）
