现代检验医学杂志2016，Vol.31Issue(3)：81-83,3.DOI:10.3969/j.issn.1671-7414.2016.03.022
基质金属蛋白酶-9在类风湿性关节炎中的诊断价值研究
Assessing the Role of Matrix Metalloproteinase-9 in Rheumatoid Arthritis
欧水连 1潘志锋 1徐灼均 1梁映亮 1邬静怡 1莫和国1
作者信息
- 1. 南方医科大学附属小榄医院检验科，广东中山 528400
- 折叠
摘要
Abstract
Objective To assess the role of Matrix Metalloproteinase-9 (MMP-9)in rheumatoid arthritis (RA).Methods Peripheral blood from 45 RA patients and 28 healthy individuals (HV)were collected to detect RF and hs-CRP by immuno-turbidimetry,ESR by westergren method and MMP-9 by ELISA.The correlation was analysed between MMP-9 and RF, ESR or hs-CRP,respectively,by pearson correlation analysis.Results Levels of RF,ESR,hs-CRP and MMP-9 were signifi-cantly higher in RA patients than HV group (t=3.93~5.96,P<0.001),respectively.RF high titer patients or patients with a high inflammation response showed a higher MMP-9 levels than the RF low titer or slight inflammation patients (P<0.05).MMP-9 was positively correlated to RF,ESR and hs-CRP in RA patients(P<0.05),respectively.Conclusion MMP-9 maybe a sensitive tool in the diagnosis and management of RA patients.关键词
类风湿性关节炎/基质金属蛋白酶-9/类风湿因子Key words
rheumatoid arthritis(RA)/matrix metalloproteinase-9(MMP-9)/rheumatoid factor(RF)分类
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欧水连,潘志锋,徐灼均,梁映亮,邬静怡,莫和国..基质金属蛋白酶-9在类风湿性关节炎中的诊断价值研究[J].现代检验医学杂志,2016,31(3):81-83,3.
