天津中医药2016，Vol.33Issue(6)：373-377,5.DOI:10.11656/j.issn.1672-1519.2016.06.14
基于IL-7的甘草多糖抗肿瘤机制的研究
Study on the anti-tumor effect mechanism of Gancao polysaccharide on production of IL-7
摘要
Abstract
[Objective] To elucidate the mechanism of Gancao polysaccharide (GP) on anti-tumor. [Methods] CT-26 cells were used to set up the tumor-bearing model in mice. The mice were respectively divided into following groups:normal group, model group, GP group (GP i.g, 500 mg/kg), letinan group (letinan i.g, 195 mg/kg) and IL-7 antibody group (GP i.g, 500 mg/kg, IL-7antibody i.p,.0.4 mg/kg on day 0, 5 and 10). After administration of GP for 14 days , the tumor, spleen and thymus were weighted to measure the tumor inhibition rat, spleen index and thymus index. [Results] After the administration of GP for 14 days, the tumor inhibition rate in GP group was 21.56%. The IL-7 gene expression in GP group was upregulated and the serum level of IL-7 was increased in GP group. The tumor inhibition rate and thymus index were decreased in IL-7 antibody group followed by the significant lower IL-7 level in serum in spite of the IL-7 gene expressed in intestine. [Conclusion] This study demonstrated that GP exert significant anti-tumor effect and the mechanism behind the anti-tumor effect may relate to the IL-7 production of intestinal epithelial cells.关键词
甘草多糖/小肠黏膜上皮细胞/抗肿瘤/白细胞介素-7Key words
Gancao polysaccharide/small intestinal mucosal epithelial cell/anti-tumor/IL-7分类
医药卫生引用本文复制引用
王丽,赵颖,崔换天,李薇,宋新波,边育红..基于IL-7的甘草多糖抗肿瘤机制的研究[J].天津中医药,2016,33(6):373-377,5.基金项目
国家科技支撑计划基金资助项目（2011BAI07B02-5）。 （）
