现代医药卫生2016，Vol.32Issue(11)：1638-1641,4.DOI:10.3969/j.issn.1009-5519.2016.11.013
支气管超声内镜引导下125I放射性粒子植入治疗纵隔淋巴结转移肿瘤的临床应用
Clinical application of endoscopic bronchial ultrasonography guided iodine-125 radioactive seeds implantation in treat-ing mediastinal metastatic tumor
夏静 1李长毅 1袁耿彪 2王导新1
作者信息
- 1. 重庆医科大学附属第二医院 呼吸科，重庆400010
- 2. 重庆医科大学附属第二医院 核医学科，重庆400010
- 折叠
摘要
Abstract
Objective To investigate the feasibility of endoscopic bronchial ultrasonography (EBUS)guided iodine-125 (125I)radioactive seeds implantation for treating mediastinal metastatic tumor and to observe its short term curative effect. Methods Twenty patients with mediastinal metastatic tumor in the respiration department of our hospital from September 2014 to March 2015 were treated by the EBUS-guided iodine-125 radioactive seeds interstitial implantation. The short-term effects were observed and the feasibility for treating mediastinal metastatic tumor was retrospectively analyzed. Results The operation procedure of the EBUS-guided iodine-125 radioactive seeds implantation brachytherapy in 20 cases of mediastinal metastatic tumor was successful. All cases had good tolerance without death case. The complications included intraoperative bleeding at puncture site in 3 cases (15%),postoperative pneumothorax in 4 cases(20%),low fever in 5 cases(25%),hemoptysis in 7 cases(35%),which were alle-viated after symptomatic treatment. Postoperative follow-up chest CT was carried out every 2 months in all cases. The tumor diam-eter and physical status of all patients were obtained during follow-up. The response evaluation criteria in solid tumors (RECIST) were used to evaluate the therapeutic effect,the overall response rates(CR+PR) at postoperative 2,4,6 months were 65.00%(13/20), 80.00%(16//20) and 85.0%(17/20)respectively. The clinical symptoms in 5 cases of superior vena cava syndrome (SVCS) were significantly improved by the above treatment and the symptom alleviation reached 100.00%after 6-month follow up. No radioac-tive seeds shift and restenosis of superior vena cava occurred in any case. Conclusion The EBUS-guided iodine-125 radioactive seeds implantation for treating mediastinal metastatic tumor has small trauma,few complications and obvious short term effect,can effectively alleviate the pressure symptoms of superior vena cava,which is a feasible,safe and effective measure.关键词
支气管镜检查/超声检查,多普勒/碘125/放射性粒子/纵隔/肿瘤转移Key words
Bronchoscopy/Ultrasonography,doppler/Iodine 125/Radioactive seeds/Mediastinum/Neo-plasm metastasis引用本文复制引用
夏静,李长毅,袁耿彪,王导新..支气管超声内镜引导下125I放射性粒子植入治疗纵隔淋巴结转移肿瘤的临床应用[J].现代医药卫生,2016,32(11):1638-1641,4.
