燕山大学学报2016，Vol.40Issue(1)：29-34,6.DOI:10.3969/j.issn.1007-791X.2016.01.005
功能酰胺化合物制备超分子凝胶材料及药物释放性能研究
Preparation of supramolecular gel materials by functional amide compound and investigation of drug release properties
摘要
Abstract
A new amide compound with aromatic substituted group was designed and synthesized. And some supramolecular gel materials were successfully prepared.SEM was utilized to characterize the morphologies of gel materials.Meanwhile using Congo red as the drug model the drug release behaviors of the as⁃prepared supramolecular gels with n⁃pentanol serving as the solvent of were carefully investigated.The influence of the factors to the drug release involving molecular structures of gelator drug concentration and release time were focused.The experimental data indicated that the obtained gels are of network structure composed of organized belt⁃like nanofibers. For the addition of Congo red with different concentrations the gel⁃drug systems showed different release capacities.The gel system with lower drug concentrations showed rapid release dynamics and bigger maximum release rate. The present work would benefit the studies of the design and preparation of gel materials and the practical application of drug delivery.关键词
超分子凝胶/自组装/凝胶剂/药物释放/纳米材料Key words
supramolecular gel/self-assembly gelator/drug release/nanomaterials分类
化学化工引用本文复制引用
袁华,罗小娜,侯彩丽,郭荣,乔玉卿,周靖欣,焦体峰..功能酰胺化合物制备超分子凝胶材料及药物释放性能研究[J].燕山大学学报,2016,40(1):29-34,6.基金项目
国家自然科学基金资助项目（21473153）；河北省自然科学基金资助项目（B2013203108）；河北省青年拔尖人才支持计划项目；河北省高等学校科学技术研究优秀青年基金资助项目（ YQ2013026）；中国博士后科学基金资助项目（2015M580214）；河北省科技厅科技支撑计划（13274803）；秦皇岛市科学技术研究与发展计划项目 （）
