摘要
Abstract
Due in part to remarkable advances over the past decade in our understanding of lung cancer, particu-larly in area of medical oncology, molecular biology, and radiology, there is a pressing need for a revised classiifcation, based not on pathology alone, but rather on an integrated multidisciplinary approach to classiifcation of lung cancer. hTe 2015 World Health Organization (WHO) Classiifcation of Tumors of the Lung, Pleura, hTymus and Heart has just been published with numerous important changes from the 2004 WHO classiifcation. hTe revised classiifcation has been greatly improved in help-ing advance the ifeld, increasing the impact of research, improving patient care and assisting in predicting outcome. hTe most significant changes will be summarized in this paper as follows:(1) main changes of lung adenocarcinoma as proposed by the 2011 International Association for the Study of Lung Cancer/American hToracic Society/European Respiratory Society (IASLC/ATS/ERS) classiifcation, (2) reclassifying squamous cell carcinomas into keratinizing, nonkeratinizing, and basaloid subtypes with the nonkeratinizing tumors requiring immunohistochemistry proof of squamous differentiation, (3) restricting the diagnosis of large cell carcinoma only to resected tumors that lack any clear morphologic or immunohistochemical differ-entiation with reclassiifcation of the remaining former large cell carcinoma subtypes into different categories, (4) grouping of neuroendocrine tumors together in one category, (5) and the current viewpoint of histologic grading of lung cancer.关键词
WHO分类/肺肿瘤/组织学分级Key words
WHO classiifcation/Lung neoplasms/Histologic grade
