中国肺癌杂志2016，Vol.19Issue(7)：418-424,7.DOI:10.3779/j.issn.1009-3419.2016.07.03
合并重症肌无力的胸腺瘤患者术后生存的初步分析--ChART数据库回顾性结果
Postoperative Survival for Patients with Thymoma Complicating Myasthenia Gravis- Preliminary Retrospective Results of the ChART Database
汪昉睿 1张仁泉 2李印 3陈克能 4陈和忠 5刘永煜 6崔有斌 7王允 8于振涛 9周鑫明 10柳阳春 11庞烈文 1刘媛 12谷志涛 12方文涛 12傅剑华 13沈毅 14魏煜程 14谭黎杰 15张鹏 16韩泳涛 17陈椿18
作者信息
- 1. 200032上海，复旦大学附属华山医院胸外科
- 2. 230022合肥，安徽医科大学附属第一医院胸外科
- 3. 450008郑州，郑州大学附属肿瘤医院胸外科
- 4. 100142北京，北京大学附肿瘤医院胸外科
- 5. 200433上海，长海医院胸心外科
- 6. 110042沈阳，辽宁肿瘤医院胸外科
- 7. 130021长春，吉林大学附属第一医院胸外科
- 8. 610041成都，四川大学华西医院胸外科
- 9. 300060天津，天津医科大学附属肿瘤医院食管癌中心
- 10. 310022杭州，浙江省肿瘤医院胸外科
- 11. 330006南昌，江西省人民医院胸外科
- 12. 200030上海，上海交通大学附属上海胸科医院
- 13. 510060广州，中山大学附属肿瘤医院胸外科
- 14. 266001青岛，青岛大学医学院附属医院胸外科
- 15. 200032上海，复旦大学附属中山医院胸外科
- 16. 300052天津，天津医科大学附属总医院胸外科
- 17. 610041成都，四川省肿瘤医院胸外科，马可
- 18. 350001福州，福建医科大学附属协和医院胸外科
- 折叠
摘要
Abstract
Background and objectiveIt is so far not clear that how myasthenia gravis (MG) affected the prognosis of thymoma patients. The aim of this assay is to compare the postoperative survival between patients with thymoma only and those with both thymoma and MG.MethodsThe Chinese Alliance for Research in Thymomas (ChART) registry recruited patients with thymoma from 18 centers over the country on an intention to treat basis from 1992 to 2012. Two groups were formed according to whether the patient complicated MG. Demographic and clinical data were reviewed, Patients were fol-lowed and their survival status were analyzed.Results There were 1,850 patients included in this study, including 421 with and 1,429 without MG. Complete thymectomy were done in 91.2% patients in MG group and 71.0% in non-MG group (P<0.05). There were more percentage of patients with the histology of thymoma AB, B1, or B2 (P<0.05) in MG group, and more percentage of patients with MG were in Masaoka stage I and II. The 5 year and 10 year OS rates were both higher in MG group (93%vs 88%; 83%vs 81%,P=0.034) respectively. The survival rate was signiifcantly higher in patients with MG when the Masaoka staging was III/IV (P=0.003). Among patients with advanced stage thymoma (stage III, IVa, IVb), the constitu-ent ratios of III, IVa, IVb were similar between MG and Non-MG group. Histologically, however, there were signiifcantly more proportion of AB/B1/B2/B3 in the MG group while there were more C in the non-MG group (P=0.000). Univariate analyses for all patients showed that MG, WHO classiifcation, Masaoka stage, surgical approach, chemotherapy and radiotherapy and resectability were signiifcant factors, and multivariate analysis showed WHO Classiifcation, Masaoka stage, and resectability were strong independent prognostic indicators.ConclusionAlthough MG is not an independent prognostic factor, the sur-vival of patients with thymoma was superior when MG was present, especially in late Masaoka stage patients. Possible reasons included early diagnosis of the tumor, better histologic types, an overall higher R0 resection and less recurrence.关键词
胸腺瘤/重症肌无力/生存率Key words
Thymoma/Myasthenia gravis (MG)/Survival引用本文复制引用
汪昉睿,张仁泉,李印,陈克能,陈和忠,刘永煜,崔有斌,王允,于振涛,周鑫明,柳阳春,庞烈文,刘媛,谷志涛,方文涛,傅剑华,沈毅,魏煜程,谭黎杰,张鹏,韩泳涛,陈椿..合并重症肌无力的胸腺瘤患者术后生存的初步分析--ChART数据库回顾性结果[J].中国肺癌杂志,2016,19(7):418-424,7.
