中国肺癌杂志2016，Vol.19Issue(7)：459-464,6.DOI:10.3779/j.issn.1009-3419.2016.07.08
胸腺切除范围对早期胸腺上皮肿瘤预后的影响
Thymectomy versus Tumor Resection for Early-stage Thymic Malignancies：A Chi-nese Alliance for Research in Thymomas (ChART) Retrospective Database Analysis
谷志涛 1李印 2陈克能 3陈和忠 4刘永煜 5崔有斌 6王允 7庞烈文 8于振涛 9周鑫明 10柳阳春 11傅剑华 12刘媛 1方文涛 1沈毅 13魏煜程 13谭黎杰 14张鹏 15韩泳涛 16陈椿 17张仁泉18
作者信息
- 1. 200030上海，上海交通大学附属上海胸科医院
- 2. 450008郑州，郑州大学附属肿瘤医院胸外科
- 3. 100142北京，北京大学附肿瘤医院胸外科
- 4. 200433上海，长海医院胸心外科
- 5. 110042沈阳，辽宁肿瘤医院胸外科
- 6. 130021长春，吉林大学附属第一医院胸外科
- 7. 610041成都，四川大学华西医院胸外科
- 8. 200032上海，复旦大学附属华山医院胸外科
- 9. 300060天津，天津医科大学附属肿瘤医院食管癌中心
- 10. 310022杭州，浙江省肿瘤医院胸外科
- 11. 330006南昌，江西省人民医院胸外科
- 12. 510060广州，中山大学附属肿瘤医院胸外科
- 13. 266001青岛大学医学院附属医院胸外科
- 14. 200032上海，复旦大学附属中山医院胸外科
- 15. 300052天津，天津医科大学附属总医院胸外科
- 16. 610041成都，四川省肿瘤医院胸外科，马可
- 17. 350001福州，福建医科大学附属协和医院胸外科
- 18. 230022合肥，安徽医科大学附属第一医院胸外科
- 折叠
摘要
Abstract
Background and objectiveTo evaluate the surgical outcomes of tumor resection with or without total thymectomy for thymic epithelial tumors (TETs) using the Chinese Alliance for Research in Thymomas (ChART) retrospec-tive database.Methods Patients without preoperative therapy, who underwent surgery for early-stage (Masaoka-Koga stage I and II) tumors, were enrolled for the study. They were divided into thymectomy and thymomectomy groups according to the resection extent of the thymus. Demographic and surgical outcomes were compared between the two patients groups. Results A total of 1,047 patients were enrolled, with 796 cases in the thymectomy group and 251 cases in the thymomec-tomy group. Improvement rate of myasthenia gravis (MG) was higher atfer thymectomy than atfer thymomectomy (91.6%vs 50.0%,P<0.001). Ten-year overall survival was similar between the two groups (90.9% atfer thymectomy and 89.4% atfer thymomectomy,P=0.732). Overall, recurrence rate was 3.1% atfer thymectomy and 5.4% atfer thymomectomy, with no sig-niifcant difference between the two groups (P=0.149). Stratiifed analysis revealed no signiifcant difference in recurrence rates in Masaoka-Koga stage I tumors (3.2%vs 1.4%,P=0.259). However in patients with Masaoka-Koga stage II tumors, recurrence was signiifcantly less atfer thymectomy group than atfer thymomectomy (2.9%vs 14.5%,P=0.001).Conclusion hTymectomy, instead of tumor resection alone, should still be recommended as the surgical standard for thymic malignancies, especially for stage II tumors and those with concomitant MG.关键词
胸腺上皮肿瘤/重症肌无力/胸腺切除/胸腺瘤切除Key words
Thymic epithelial tumors/Myasthenia gravis/hTymectomy/hTymomectomy引用本文复制引用
谷志涛,李印,陈克能,陈和忠,刘永煜,崔有斌,王允,庞烈文,于振涛,周鑫明,柳阳春,傅剑华,刘媛,方文涛,沈毅,魏煜程,谭黎杰,张鹏,韩泳涛,陈椿,张仁泉..胸腺切除范围对早期胸腺上皮肿瘤预后的影响[J].中国肺癌杂志,2016,19(7):459-464,6.
