局解手术学杂志2016，Vol.25Issue(5)：331-334,335,5.DOI:10.11659/jjssx.12E015168
肝细胞肝癌伴脉管癌栓单纯手术切除与切除术后联合介入治疗预后对比
Prognosis of surgical excision combined with interventional therapy in treatment of hepatocellular carcinoma with microvascular invasion
摘要
Abstract
Objective The aim of this study is to analyze the long-time outcome of hepatocellular carcinoma(HCC)patients with micro-vascular invasion underwent liver resection combined with transarterial chemoembolization(TACE).Methods Our database of surgical re-section from January 2009 to September 2015 was retrospectively analyzed.This study was conducted on 296 HCC patients with MVI.Patients were divided into two groups:one group underwent liver resection (n =159)and another for liver resection combined with TACE (n =137). The 5-year overall survival rate (OS)and disease free survival (DFR)were compared.A multivariate Cox proportional hazards regression a-nalysis was performed to assess the prognostic risk factors associated with overall survival rate.Results The 5-year OS and 5-year DFR see significant difference (OS:18% vs.8%,P =0.001;TRF:15% vs.8%,P =0.008).Multivariate analysis revealed that HBsAg(HR 1.596, P =0.002,95% CI 1.194 ~2.131),tumor size >5 cm(HR 0.729,P =0.042,95% CI 0.539 ~0.989)as well as multiple tumors(HR 1.480,P =0.049,95% CI 1.002 ~2.186)were correlated to poor overall survival rate.Conclusion Surgical resection combined TACE for HCC patients with MVI realized a better prognosis than patients merely underwent therapy of resection.关键词
肝细胞肝癌/手术切除/介入治疗/预后/总体生存率/无瘤生存率Key words
hepatocellular carcinoma/excison/interventional therapy/prognosis/overall survival/disease free survival分类
医药卫生引用本文复制引用
刘嘉烨,李川,天夫,严律南,杨家印,李波,王文涛,徐明清,吴泓..肝细胞肝癌伴脉管癌栓单纯手术切除与切除术后联合介入治疗预后对比[J].局解手术学杂志,2016,25(5):331-334,335,5.基金项目
国家自然科学基金（2012ZX10002-016，2012ZX10002-017）；四川省科技厅支撑计划慢性病毒性肝炎及重症肝病综合防治研究 （）
