局解手术学杂志2016，Vol.25Issue(5)：339-341,342,4.DOI:10.11659/jjssx.02E016037
外周血 CD64指数对创伤手术后脓毒症的早期诊断价值
Early diagnosis value of CD64 index levels in peripheral blood on postoperative traumatic sepsis
摘要
Abstract
Objective To investigate the expression and early diagnosis value of CD64 index levels in peripheral blood cells in patients with postoperative traumatic sepsis.Methods A number of 420 trauma patients were enrolled in the study,and they were divided into the postoperative traumatic sepsis group(130 cases)and postoperative general trauma group(290 cases)according to the clinical manifestations. The CD64 levels in peripheral blood were measured by flow cytometry,and the levels of C-reactive protein(CRP)and white blood cell count (WBC)were detected.The diagnostic value of these indexes on postoperative traumatic sepsis were evaluated.Results The CD64 index, CRP and WBC levels in postoperative traumatic sepsis group were significantly higher than postoperative general trauma group(P <0.05). After appropriate treatment,the CD64 index,CRP and WBC levels decreased significantly compared with the preoperative levels(P <0.05). The correlation analysis showed that the CD64 index in peripheral blood and CRP level were positively correlated(r =0.79,P <0.01).How-ever,the CD64 index in peripheral blood and WBC level were of no significant correlation(r =0.028,P >0.05).The ROC curve analysis showed that when CD64 index(7.21)considered as the boundary for early diagnosis of postoperative traumatic sepsis,the sensitivity and spe-cificity of diagnosis for postoperative traumatic sepsis were 85.1% and 87.8%,the area under the ROC curve(AUC)was 0.865(95%CI 0.784 ~0.929),which was significantly better than CRP index.Conclusion The expression of CD64 is higher in patients with postoperative traumatic sepsis,which can be used as an effective indicator for early diagnosis of postoperative traumatic sepsis,and it has an important clin-ical application value.关键词
CD64指数/创伤/脓毒症/诊断Key words
CD64 index/trauma/sepsis/diagnosis分类
医药卫生引用本文复制引用
卢海滨,周健,王耀丽,陈玺..外周血 CD64指数对创伤手术后脓毒症的早期诊断价值[J].局解手术学杂志,2016,25(5):339-341,342,4.基金项目
重庆市卫生计生委医学科研计划项目 （）
