中国康复理论与实践2016，Vol.22Issue(6)：635-639,5.DOI:10.3969/j.issn.1006-9771.2016.06.003
不同频率电针对阿尔茨海默病大鼠学习记忆能力和海马突触的影响
Effect of Electroacupuncture with Different Frequencies on Learning and Memory Ability and Synapse in Hippo-camp in Rats with Alzheimer's Disease
摘要
Abstract
Objective To observe the effect of electroacupuncture with different frequencies on learning and memory ability, synaptic morphology and synaptic density in the hippocampus of Alzheimer's disease rats. Methods Forty-eight healthy Wistar rats were randomly di-vided into normal group, sham operation group, model group, 2 Hz, 30 Hz and 50 Hz electroacupuncture groups with 8 cases in each group. The Alzheimer's disease model was established by injecting Aβ1-42 into two sides of lateral cerebral ventricle. The sham operation group was injected with normal saline instead. The electroacupuncture groups received electroacupuncture at Baihui (DU20) and Shenshu (BL23) acu-points. The learning and memory ability was evaluated with Morris water maze test, and the morphology and density of synapse were ob-served by electron microscope. Results Compared with the model group, the latency was shorter, the time of crossing the platform was short-er and the number of crossing the platform was more in the electroacupuncture groups (P<0.01), especially in the 50 Hz electroacupuncture group (P<0.01). The number of synapse and the synaptic density were more in the electroacupuncture groups than in the model group (P<0.01), especially in the 50 Hz electroacupuncture group (P<0.01). Conclusion Electroacupuncture could improve learning and memory abili-ty and increase synaptic density in rats with Alzheimer's disease, especially with high frequency.关键词
阿尔茨海默病/电针/频率/学习记忆能力/突触密度/大鼠Key words
Alzheimer's disease/electroacupuncture/frequency/learning and memory ability/synaptic density/rats分类
医药卫生引用本文复制引用
王颖,李威,张亢亢,王慧,孔立红..不同频率电针对阿尔茨海默病大鼠学习记忆能力和海马突触的影响[J].中国康复理论与实践,2016,22(6):635-639,5.基金项目
国家自然科学基金项目(No.81373741)。 （No.81373741）
