中国药房2016，Vol.27Issue(17)：2364-2366,3.DOI:10.6039/j.issn.1001-0408.2016.17.20
西格列汀联合二甲双胍治疗2型糖尿病合并代谢综合征的临床观察Δ
Clinical Observation of Sitagliptin Combined with Metformin in the Treatment of Type 2 Diabetes Compli-cating with Metabolic Syndrome
摘要
Abstract
OBJECTIVE:To observe clinical efficacy and safety of sitagliptin combined with metformin in the treatment of type 2 diabetes complicating with metabolic syndrome. METHODS:Totally 80 patients with type 2 diabetes complicating with meta-bolic syndrome were divided into the observation group and control group with 40 cases in each group according to simple random sampling method. Both groups were given same diet and exercise plan;control group was additionally given metformin orally,0.5 g each time,tid;observation group was additionally given sitagliptin,100 mg each time,qd,on the basis of control group. Treat-ment course of 2 groups lasted for 12 weeks. The waist circumference(WC),body mass index(BMI),blood glucose,blood lip-id,fasting insulin (FINS) and serum adiponectin were detected in 2 groups,and steady-state model insulin resistance index (HOMA-IR)and whole body insulin sensitivity index(WBISI)were calculated. The occurrence of ADR was observed. RESULTS:Before treatment,there were no statistically significant differences between 2 groups in WC,BMI,systolic blood pressure,diastol-ic blood pressure,triglycerides,cholesterol,high-density lipoprotein cholester,low-density lipoprotein cholesterol,fasting plasma glucose,2 h postprandial blood glucose,FINS,HOMA-IR,WBISI and serum adiponectin(P>0.05). After treatment,the above indexes of 2 groups were obviously improved,and the improvement of observation group was significantly better than that of con-trol group,with statistical significance(P<0.05). 2 cases and 3 cases were withdraw from the study in control group and observa-tion group because of ADR,respectively.There was no statistically significant difference in the incidence of ADR between 2 groups (P>0.05). CONCLUSIONS:Sitagliptin combined with metformin shows significant clinical efficacy in the treatment of type 2 di-abetes complicating with metabolic syndrome. Its mechanism may be related to reducing insulin resistance,enhancing insulin sensi-tivity,decreasing patients’body weight and up-regulating serum adiponectin level.关键词
2型糖尿病/代谢综合征/西格列汀/二甲双胍/血清脂联素/胰岛素抵抗Key words
Type 2 diabetes/Metabolic syndrome/Sitagliptin/Metformin/Serum adiponectin/Insulin resistance分类
医药卫生引用本文复制引用
张坤,任巧华,吴韬,杜俊文..西格列汀联合二甲双胍治疗2型糖尿病合并代谢综合征的临床观察Δ[J].中国药房,2016,27(17):2364-2366,3.基金项目
石家庄市科学技术研究与发展指导计划资助课题 （）
