中国药房2016，Vol.27Issue(17)：2402-2404,3.DOI:10.6039/j.issn.1001-0408.2016.17.33
丹参多酚酸盐治疗慢性阻塞性肺疾病急性加重期的临床观察
Clinical Observation of Salvianolate in the Treatment of Acute Exacerbation of Chronic Obstructive Pulmo-nary Disease
李树铁 1汪业铭 1李媛莉 1陈琛 1王磊 1姜伟 1李福龙1
作者信息
- 1. 河北北方学院附属第一医院重症医学科，河北张家口 075000
- 折叠
摘要
Abstract
OBJECTIVE:To observe clinical efficacy and safety of salvianolate in the treatment of acute exacerbation of chron-ic obstructive pulmonary disease(AECOPD). METHODS:80 AECOPD patients were selected and randomly divided into observa-tion group and control group,with 40 cases in each group. Both groups received mechanical ventilation. Control group was given routine treatment of theophyllinum,bronchodilators and glucocorticoid;treatment group was additionally given Salvianolate injec-tion 200 mg,qd,ivgtt,on the basis of control group. Clinical efficacy was observed in 2 groups,blood hemorheology indexes were also observed before and after treatment. The mechanical ventilation time,ICU residence time and ADR were recorded in 2 groups. RESULTS:Clinical total effective rate of observation group was 95.00%,which was significantly higher than 70.00% of control group,with statistical significance(P<0.05). Before treatment and 2 d after treatment,blood rheology indexes of treatment group were improved significantly(all P>0.05),and whole blood reduction viscosity of control group was improved significantly(P<0.05). Mechanical ventilation time and ICU residence time of treatment group was significantly shorter than that of control group (P<0.05). No ADR was found in 2 groups. CONCLUSIONS:Salvianolate can significantly improve the blood coagulation status of AECOPD patients receiving invasive mechanical ventilation,and has the advantages of good clinical efficacy and low cost of medical treatment.关键词
丹参多酚酸盐/慢性阻塞性肺疾病急性加重期/有创机械通气/疗效Key words
Salvianolate/AECOPD/Invasive mechanical ventilation/Clinical efficacy分类
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李树铁,汪业铭,李媛莉,陈琛,王磊,姜伟,李福龙..丹参多酚酸盐治疗慢性阻塞性肺疾病急性加重期的临床观察[J].中国药房,2016,27(17):2402-2404,3.
