中国药房2016，Vol.27Issue(17)：2415-2416,2417,3.DOI:10.6039/j.issn.1001-0408.2016.17.38
西酞普兰治疗肺癌术后抑郁症的临床观察
Clinical Observation of Citalopram in the Treatment of Depression after Lung Cancer Operation
孙振卿 1郭强 1李鹤飞 1王海波 1祖金池 1石林 1张越 1李亚静 1桑文华2
作者信息
- 1. 河北大学附属医院胸外科，河北保定 071000
- 2. 河北省精神卫生中心情感障碍科，河北保定 071000
- 折叠
摘要
Abstract
OBJECTIVE:To observe clinical efficacy and safety of citalopram in the treatment of depression patients after lung cancer operation. METHODS:114 depression patients after lung cancer operation were selected and randomly divided into observa-tion group and control group (n=57). Control group was given routine treatment as nutrition support and electrolyte balance,but had no anti-depression drugs;observation group was given Citalopram tablet 20 mg orally,qd. Two groups were treated for 6 weeks. Clinical efficacy,HAMD and HAMA scores,each score and total score of SF-36 were observed before and after treatment. The occurrence of ADR was recorded. RESULTS:The total effective rate of observation group was 87.72%,which was significant-ly higher than that that of control group(71.93%),with statistical significance(P<0.05);there was no statistical significance in HAMA score,HAMD score,each score and total score of SF-36 between 2 groups before treatment(P>0.05);HAMA score and HAMD score of 2 groups decreased significantly after treatment,the observation group was lower than the control group;each score and total score of SF-36 increased significantly,the observation group was higher than the control group,with statistical sig-nificance(P<0.05). No obvious ADR was found in 2 groups. CONCLUSIONS:Citalopram is effective and safe for depression af-ter lung cancer operation,can improve mental state and quality of life.关键词
西酞普兰/抑郁症/安全性/肺癌Key words
Citalopram/Depression/Safety/Lung cancer分类
医药卫生引用本文复制引用
孙振卿,郭强,李鹤飞,王海波,祖金池,石林,张越,李亚静,桑文华..西酞普兰治疗肺癌术后抑郁症的临床观察[J].中国药房,2016,27(17):2415-2416,2417,3.
