中国药理学通报2016，Vol.32Issue(6)：747-750,4.DOI:10.3969/j.issn.1001-1978.2016.06.002
tuftsin及其衍生物T肽的抗癌作用研究进展
Research progress on anti-cancer effects of tuftsin and its derivatives
摘要
Abstract
tuftsin,a physiologically active peptide,can promote phagocytosis,basically stimulates the macrophages or neutro-phils and improve their phagocytotic function.tuftsin can not di-rectly kill tumor cells.Due to its short structure and the charac-teristics of being susceptible to hydrolysis,it is difficult for tuft-sin to be made into medicine and applied clinically.However, derivatives of tuftsin-series and combination of tuftsin with other drugs can greatly enhance the cytotoxic effect on tumor cells of tuftsin.It has a broad prospect of research,especially deriva-tive-TP has a significant anti-tumor effect.Its mechanism is clear and its is expected to become a new type of anti-tumor bio-logical response regulator.关键词
tuftsin/T肽/生物抗癌/中性粒细胞/巨噬细胞/生物反应调节剂Key words
tuftsin/T peptide/biological anticancer/neutro-phils,/macrophages/biological response modifier(BRM)分类
医药卫生引用本文复制引用
安映红,袁守军..tuftsin及其衍生物T肽的抗癌作用研究进展[J].中国药理学通报,2016,32(6):747-750,4.基金项目
国家自然科学基金资助项目（No 30973564）；国家科技部“重大新药创制”科技重大专项综合新药研究开发技术大平台项目 （）
