中国药理学通报2016，Vol.32Issue(6)：751-755,5.DOI:10.3969/j.issn.1001-1978.2016.06.003
人体端粒G4-D NA稳定剂的研究进展
Study of human telomere G4-DNA stabilizers
摘要
Abstract
Telomere maintenance plays a critical role in cancer progression.Approximately 85% human cancer cells maintain their telomere length through activation of telomerase.Other 15%of cancers maintain telomere length independently of telom-erase by alternative lengthening of telomeres (ALT)pathway. Both events are equally important for telomere length mainte-nance of cancer cells.Human telomere consists of a series of G rich DNA sequences,which could form G-quadruplex.The for-mation of this structure can block the extension of telomeres by telomerase or ALT,resulting in cancer cell death.Thereby,G-quadruplex has been one of the focuses of anticancer therapy in recent years.This review focuses on the latest progress of G-quadruplex stabilizers.关键词
癌症/端粒/端粒酶/端粒替代延伸机制(ALT)/G-四链体 DNA/有机小分子/金属配合物Key words
cancer/telomere/telomerase/alternative lengthening of telomeres (ALT)/G-quadruplex DNA/small organic mole-cules/metal complexes分类
医药卫生引用本文复制引用
郑小辉,刘海英,夏立新,毛宗万..人体端粒G4-D NA稳定剂的研究进展[J].中国药理学通报,2016,32(6):751-755,5.基金项目
国家自然科学基金资助项目（No 31271472，31322033，81273275）；博士后基金资助项目（No 2014M562208）；深圳市科技计划项目 （）
