中国药理学通报2016，Vol.32Issue(6)：764-767,4.DOI:10.3969/j.issn.1001-1978.2016.06.006
臂旁核神经元调节睡眠觉醒的研究进展
Regulatory effects of PB on sleep and wakefulness
摘要
Abstract
The parabrachial nucleus (PB)is made up of gray matter around the Pons combination(BC),mainly consisting of glutamatergic,GABAergic and enkephalinergic neurons.PB is connected to hypothalamus and basal forebrain through a network of nerve fibers.Specific lesion of the entire parabrachial complex in animals leads to a deep coma.PB also projects to the non-rapid eye movement(NREM)-related regions including the ven-trolateral preoptic,and receives the projections from the parafa-cial zone.Activation of the GABAergic neurons in parafacial zone can promote NREM sleep,which indicates that PB partici-pates in NREM sleep.Furthermore,the lateral PB is actived when rapid eye movement(REM)sleep is deprived.In conclu-sion,PB participates in regulating wakefulness, NREM and REM sleep.This review summarizes the advances in the roles of PB in sleep-wake regulation.关键词
臂旁核/觉醒/非快动眼睡眠/快动眼睡眠/谷氨酸神经元/投射Key words
parabrachial nucleus/wakefulness/NREM sleep/REM sleep/glutamatergic neuron/projection分类
医药卫生引用本文复制引用
赵敏锐,王典茹,杨解人,王毅群..臂旁核神经元调节睡眠觉醒的研究进展[J].中国药理学通报,2016,32(6):764-767,4.基金项目
国家自然科学基金面上项目 （）
